Plasmodium falciparum pre-erythrocytic stage vaccine development

被引:0
作者
Jessica Molina-Franky
Laura Cuy-Chaparro
Anny Camargo
César Reyes
Marcela Gómez
David Ricardo Salamanca
Manuel Alfonso Patarroyo
Manuel Elkin Patarroyo
机构
[1] Universidad de Boyacá,Health Sciences Faculty
[2] Fundación Instituto de Inmunología de Colombia (FIDIC),Molecular Biology and Immunology Department
[3] Universidad del Rosario,PhD Program in Biomedical and Biological Sciences
[4] Universidad de Ciencias Aplicadas y Ambientales (U.D.C.A),Animal Science Faculty
[5] Fundación Instituto de Inmunología de Colombia (FIDIC),3D Structures Department
[6] Universidad del Rosario,Basic Sciences Department, School of Medicine and Health Sciences
[7] Universidad Nacional de Colombia,Medical School
来源
Malaria Journal | / 19卷
关键词
Malaria; Vaccine; Sporozoite; Clinical trial; Vaccine efficacy; Immune response;
D O I
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中图分类号
学科分类号
摘要
Worldwide strategies between 2010 and 2017 aimed at controlling malarial parasites (mainly Plasmodium falciparum) led to a reduction of just 18% regarding disease incidence rates. Many biologically-derived anti-malarial vaccine candidates have been developed to date; this has involved using many experimental animals, an immense amount of work and the investment of millions of dollars. This review provides an overview of the current state and the main results of clinical trials for sporozoite-targeting vaccines (i.e. the parasite stage infecting the liver) carried out by research groups in areas having variable malaria transmission rates. However, none has led to promising results regarding the effective control of the disease, thereby making it necessary to complement such efforts at finding/introducing new vaccine candidates by adopting a multi-epitope, multi-stage approach, based on minimal subunits of the main sporozoite proteins involved in the invasion of the liver.
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