Activity of Nitric Oxide Synthase and Concentration of Nitric Oxide End Metabolites in the Gingiva under Experimental Pathological Conditions

被引：0
|
作者：
V. L. Popkov
I. A. Fil'chukova
N. V. Lapina
V. P. Galenko-Yaroshevskii
A. S. Dukhanin
机构：
[1] Russian Academy of Medical Sciences,Krasnodar Branch, Southern Bureau
[2] Russian State Medical University,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2005年 / 140卷
关键词：
NO; NO synthase; experimental pathology;
D O I：
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学科分类号：
摘要：
Parameters of NO metabolism in the gingiva were studied during experimental periodontitis accompanied by alloxan diabetes and exogenous hypercholesterolemia. We measured activities of inducible and constitutive NO synthase and concentrations of stable NO end metabolites in rat gingival tissue (total contents of nitrite and nitrate). Under pathological conditions NO metabolism significantly differed from the control. Treatment with mexidol for 14 days significantly decreased activity of inducible NO synthase in the gingiva of experimental animals.
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页码：391 / 393
页数：2
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