The individual’s signature of telomere length distribution

被引：0

作者：

Simon Toupance

Denis Villemonais

Daphné Germain

Anne Gegout-Petit

Eliane Albuisson

Athanase Benetos

机构：

[1] Université de Lorraine,

[2] Inserm,undefined

[3] DCAC,undefined

[4] Université de Lorraine,undefined

[5] CHRU-Nancy,undefined

[6] Pôle “Maladies du Vieillissement,undefined

[7] Gérontologie et Soins Palliatifs”,undefined

[8] Nancyclotep-GIE,undefined

[9] Université de Lorraine,undefined

[10] Ecole des Mines,undefined

[11] Université de Lorraine,undefined

[12] CNRS,undefined

[13] Inria,undefined

[14] IECL,undefined

[15] Université de Lorraine,undefined

[16] CHRU de Nancy,undefined

[17] BIOBASE,undefined

[18] Pôle S2R,undefined

[19] Université de Lorraine,undefined

[20] InSciDenSe,undefined

来源：

Scientific Reports | / 9卷

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摘要：

Mean telomere length in human leukocyte DNA samples reflects the different lengths of telomeres at the ends of the 23 chromosomes and in an admixture of cells. However, only rudimentary information is available regarding the distribution of telomere lengths in all chromosomes and the different cell types in leukocyte samples. Understanding the configuration of leukocyte telomere length distribution (LTLD) could be helpful in capturing intrinsic elements that are not provided by the mean leukocyte telomere length (mLTL). The objective of this study was to analyse LTLD and its temporal variation in adults. Leukocyte samples were donated on two occasions (8 years apart) by 72 participants in the ADELAHYDE study. Telomere length was measured by Southern blotting of the terminal restriction fragments. Individuals with comparable mLTLs displayed different shapes of LTLDs. Inter-individual variation in LTLD shape was much larger than intra-individual variation in LTLD shape between baseline and follow-up leukocyte samples. These results show an important individual stability of LTLD shape over time indicating that each individual has a characteristic LTLD signature.

引用

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