Synthesis and anti-inflammatory and analgesic activities of phenoxyalkanoic acid derivatives

被引：0

作者：

Kuk Hyun Shin

Eun Bang Lee

Sang Woo Park

Kye Jung Shin

Dong Chan Kim

Dong Jin Kim

机构：

[1] Korea Institute of Science and Technology,Division of Applied Sciences

[2] Seoul National University,Natural Products Research Institute

来源：

Archives of Pharmacal Research | 1997年 / 20卷

关键词：

Phenoxyalkanoic acid derivatives; Anti-inflammatory activity; Analgesic activity; Carrageenin-induced paw edema; Acetic acid writhing syndrome; Tail clip pressure test;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The synthesis of phenoxyalkanoic acid derivatives and their anti-inflammatory and analgesic activities are described. Analysis of structure-activity relationships shows that in trichlorophenoxy derivatives anti-edematous potency is associated with the presence of 1-thiopropyl moiety and 2 or 4-aminopyridyl moiety at R′ position contributes to the analgesic activity.

引用

页码：72 / 75

页数：3

共 12 条

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Kendall E.C.(1966)A modification of Hoffner's method for testing analgesics Jpn. J. Pharmacol. 16 287-294

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Slocumb C.H.(1964)The use of changes in capillary permeability in mice to distinguish between narcotic and non-narcotic analgesics Br. J. Pharmacol. Chemother. 22 246-252

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[6]

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