Synthesis and anti-inflammatory and analgesic activities of phenoxyalkanoic acid derivatives

被引：0
|
作者：
Kuk Hyun Shin
Eun Bang Lee
Sang Woo Park
Kye Jung Shin
Dong Chan Kim
Dong Jin Kim
机构：
[1] Korea Institute of Science and Technology,Division of Applied Sciences
[2] Seoul National University,Natural Products Research Institute
来源：
Archives of Pharmacal Research | 1997年 / 20卷
关键词：
Phenoxyalkanoic acid derivatives; Anti-inflammatory activity; Analgesic activity; Carrageenin-induced paw edema; Acetic acid writhing syndrome; Tail clip pressure test;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The synthesis of phenoxyalkanoic acid derivatives and their anti-inflammatory and analgesic activities are described. Analysis of structure-activity relationships shows that in trichlorophenoxy derivatives anti-edematous potency is associated with the presence of 1-thiopropyl moiety and 2 or 4-aminopyridyl moiety at R′ position contributes to the analgesic activity.
引用
收藏
页码：72 / 75
页数：3
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