Sirtuin deacetylases in neurodegenerative diseases of aging

被引：0
作者：
Adrianna Z Herskovits
Leonard Guarente
机构：
[1] Brigham and Women's Hospital,Department of Pathology
[2] Massachusetts Institute of Technology,Department of Biology
来源：
Cell Research | 2013年 / 23卷
关键词：
sirtuin; histone deacetylase; Alzheimer's disease; Parkinson's disease; Huntington's disease; amyotrophic lateral sclerosis; spinal and bulbar muscular atrophy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Sirtuin enzymes are a family of highly conserved protein deacetylases that depend on nicotinamide adenine dinucleotide (NAD+) for their activity. There are seven sirtuins in mammals and these proteins have been linked with caloric restriction and aging by modulating energy metabolism, genomic stability and stress resistance. Sirtuin enzymes are potential therapeutic targets in a variety of human diseases including cancer, diabetes, inflammatory disorders and neurodegenerative disease. Modulation of sirtuin activity has been shown to impact the course of several aggregate-forming neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis and spinal and bulbar muscular atrophy. Sirtuins can influence the progression of neurodegenerative disorders by modulating transcription factor activity and directly deacetylating proteotoxic species. Here, we describe sirtuin protein targets in several aggregate-forming neurodegenerative diseases and discuss the therapeutic potential of compounds that modulate sirtuin activity in these disorders.
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页码：746 / 758
页数：12
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