Expression of MMP2 and MMP9 (Gelatinases A and B) in Human Colon Cancer Cells

被引：0
作者：
Umadevi Damodharan
Ravikumar Ganesan
Uma C. Radhakrishnan
机构：
[1] Karpagam Arts and Science College,Department of Biochemistry
[2] Karpagam University,Department of Biochemistry
来源：
Applied Biochemistry and Biotechnology | 2011年 / 165卷
关键词：
Matrix metalloproteinase; Colon cancer; Emodin; Sodium nitroprusside; Nitric oxide;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Matrix metalloproteinases (MMPs) are a family of zinc-dependent neutral endopeptidases, collectively capable of degrading essentially all matrix components. Elevated levels of distinct MMPs are detected in tumor tissue or serum of patients with advanced cancer, and they are the major prognostic indicators in cancer. Inhibition of MMPs has been explored as a therapeutic goal for almost two decades. Nitric oxide (NO), a free radical plays an important role in signaling pathways in regulation of MMP expression. In the present study, we demonstrated the role of exogenous NO levels in the regulation of MMP2 and MMP9 (gelatinases A and B) in colon cancer cell line WiDr and its inhibition with emodin (a naturally occurring anthraquinone).
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页码：1245 / 1252
页数：7
相关论文
共 58 条
  • [1] Wittekind C(2005)undefined Oncology 69 14-16
  • [2] Neid M(1997)undefined Journal of the National Cancer Institute 89 1260-1270
  • [3] Ann FC(2003)undefined Journal of Biochemistry and Molecular Biology 36 128-137
  • [4] Lynn MM(2002)undefined Cell Research 12 311-320
  • [5] Sang-Oh Y(2006)undefined Nature Reviews Cancer 6 521-534
  • [6] Soo-Jin P(2002)undefined Z Naturforsch 57c 923-929
  • [7] Chang-Hyun Y(2007)undefined Molecular Cancer Therapy 6 987-994
  • [8] An-Sik C(2001)undefined British Journal of Pharmacology 134 11-20
  • [9] Weiming X(1992)undefined Antiviral Research 17 63-67
  • [10] Li ZL(1983)undefined Journal Immunology Methodology 65 55-63
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