LKB1 and AMPK and the cancer-metabolism link - ten years after

被引：0
作者：
D Grahame Hardie
Dario R Alessi
机构：
[1] University of Dundee,Division of Cell Signalling and Immunology, College of Life Sciences
[2] University of Dundee,MRC Protein Phosphorylation Unit, College of Life Sciences
来源：
BMC Biology | / 11卷
关键词：
Metformin; AMPK Activation; Biguanides; Tumor Suppressor Function; Phenformin;
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摘要：
The identification of a complex containing the tumor suppressor LKB1 as the critical upstream kinase required for the activation of AMP-activated protein kinase (AMPK) by metabolic stress was reported in an article in Journal of Biology in 2003. This finding represented the first clear link between AMPK and cancer. Here we briefly discuss how this discovery came about, and describe some of the insights, especially into the role of AMPK in cancer, that have followed from it.
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