Age-related changes in synaptic vesicle pools of axo-dendritic synapses on hippocampal CA1 pyramidal neurons in mice

被引：0
作者：
A. G. Nikonenko
G. G. Skibo
机构：
[1] National Academy of Sciences of Ukraine,Bogomolets Institute of Physiology
来源：
Neurophysiology | 2006年 / 38卷
关键词：
age-associated changes; axo-somatic synapses; hippocampus; spatial patterns; synaptic vesicles;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The ultrastructure of symmetric (putatively inhibitory) axo-dendritic synapses on the membrane of hippocampal CA1 pyramidal neurons was investigated in young (20-day-old) and adult (1-year-old) mice. It was shown that synapses of adult animals contain, on average, fewer synaptic vesicles (SVs), and resting SVs of the reserve pool are mostly responsible for this difference. At the same time, in the synapses of adult mice SVs are localized closer to active zones, and the readily releasable pool of SVs is larger in these animals than in young mice. The observed changes in the spatial structure of SV pools presumably demonstrate the age-associated adaptation of inhibitory synapses providing the maintenance of adequate functional properties of hippocampal neuronal networks.
引用
收藏
页码：344 / 347
页数：3
相关论文
共 31 条
  • [1] Peters A.(1996)The morphology of synapses J. Neurocytol. 25 687-700
  • [2] Palay S. L.(2001)A GABA(B) mystery: the search for pharmacologically distinct GABA(B) receptors Mol. Int. 1 208-218
  • [3] Enna S. J.(2005)Hippocampal gamma-frequency oscillations: from interneurons to pyramidal cells, and back J. Physiol. 562 55-63
  • [4] Mann E. O.(1994)Loss of calbindin-immunoreactivity in Brain Res. 661 181-1998
  • [5] Radcliffe C. A.(1986) hippocampal stratum radiatum and stratum lacunosum-moleculare interneurons in the aged rat J. Microsc. 142 259-276
  • [6] Paulsen O.(2004)Estimation of surface area from vertical sections Microsc. Res. Tech. 65 287-291
  • [7] Potier B.(2001)Technique to quantify local clustering of synaptic vesicles using single section data J. Comp. Neurol. 439 65-72
  • [8] Krzywkowski P.(1992)Age-related decline of presumptive inhibitory synapses in the sensorimotor cortex as revealed by the physical disector J. Submicrosc. Cytol. Pathol. 24 351-357
  • [9] Lamour Y.(1995)Age-related quantitative changes in inhibitory axo-somatic synapses on Purkinje cells of rat neocerebellum (Crus I and Crus II) J. Neurophysiol. 74 539-546
  • [10] Dutar P.(2006)Decreased monosynaptic GABA Neuroscience 142 187-201
1234