Pulmonary hypertension and right ventricular dysfunction in growth-restricted, extremely low birth weight neonates

被引：40

作者：

Danhaive O. ^{[1
,2
]}

Margossian R. ^{[3
]}

Geva T. ^{[3
]}

Kourembanas S. ^{[2
]}

机构：

[1] Department of Neonatology, Bambino Gesù Children's Hospital, Rome 00165

[2] Division of Newborn Medicine, Children's Hospital, Boston, MA

[3] Department of Cardiology, Children's Hospital, Boston, MA

来源：

Journal of Perinatology | 2005年 / 25卷 / 7期

关键词：

D O I：

10.1038/sj.jp.7211299

中图分类号：

学科分类号：

摘要：

This case series reports an acute episode of hypoxemia and systemic hypotension in seven infants under 1 kg, taking place several hours or days after birth, after a period of stability and in the absence of significant lung disease. These patients were growth-restricted at birth and had a history of chronic fetal hypoxia and oligohydramnios. Pulmonary hypertension and right ventricular dysfunction were found by echocardiography. Right ventricular ejection fraction was significantly depressed during the acute episode, compared to baseline values measured after recovery. The timing of symptoms seemed related to ductus arteriosus closure or constriction. Oxygenation and right ventricular function improvement occured within a few days under ventilatory and inotropic support, while milrinone was administered in five cases. In conclusion, pulmonary hypertension is a rare but significant cause of hypoxemia in preterm infants, and pulmonary vasolidator therapy should be considered in the presence of right ventricular dysfunction. © 2005 Nature Publishing Group All rights reserved.

引用

页码：495 / 499

页数：4

共 24 条

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