Synthesis of novel 2-[4-(4-substitutedbenzamido/phenylacetamido)phenyl]benzothiazoles as antimicrobial agents

被引：0
|
作者：
Kayhan Bolelli
Ismail Yalcin
Tugba Ertan-Bolelli
Selda Özgen
Fatma Kaynak-Onurdag
Ilkay Yildiz
Esin Aki
机构：
[1] Ankara University,Department of Pharmaceutical Chemistry, Faculty of Pharmacy
[2] Gazi University,Department of Pharmaceutical Microbiology, Faculty of Pharmacy
来源：
Medicinal Chemistry Research | 2012年 / 21卷
关键词：
Benzothiazole; Antibacterial activity; Antifungal activity; Multi-drug resistance;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A new series of 2-[4-(4-substitutedbenzamido/phenylacetamido)phenyl] benzothiazole derivatives (6a–k) were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Escherichia coli with their drug-resistant isolates and a yeast Candida albicans. Microbiological results indicated that the compounds possessed a broad spectrum of activity against the tested microorganisms at minimum inhibitory concentration (MIC) values between 100 and 6.25 μg/ml. Compounds 6d and 6k exhibited significant antibacterial activity showing 6.25 μg/ml MIC values against drug-resistant S. aureus and P. aeruginosa isolates, respectively.
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收藏
页码：3818 / 3825
页数：7
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