Role of cytomegalovirus infection in the incidence of viral acute respiratory infections in children attending day-care centers

被引：0
作者：
Chomel J.-J. [1 ]
Allard J.-P. [1 ]
Floret D. [2 ]
Honegger D. [3 ]
David L. [2 ]
Lina B. [1 ]
Aymard M. [1 ]
机构：
[1] Laboratoire de Virologie, Centre Hospitalo Universitaire-Lyon, Domaine Rockefeller, 69373 Lyon Cedex 08
[2] Departments of Pediatrics, Hôpital E. Herriot, Lyon
[3] Service Santé Prévention, Conseil Général du Rhône, Lyon
来源：
European Journal of Clinical Microbiology and Infectious Diseases | 2001年 / 20卷 / 3期
关键词：
Urine Sample; Respiratory Infection; Respiratory Syncytial Virus; Acute Respiratory Infection; Respiratory Virus;
D O I：
10.1007/s100960100462
中图分类号：
学科分类号：
摘要：
In a prospective study carried out in Lyon, France, the association between the excretion of cytomegalovirus (CMV) and the increasing frequency and severity of viral respiratory infections in children attending day-care centers was evaluated. Urine samples were collected in November 1992 (S1) and 4 months later in February 1993 (S4). A total of 246 children aged 6-12 months attending 29 day-care centers from 1 November to 28 February were screened for the excretion of CMV in urine. The diagnosis of viral acute respiratory infection was performed in the case of outbreaks only. Forty-eight (19.5%) children were both S1 and S4 positive for CMV, 30 (12.4%) became CMV positive (S1-/S4+), 4 (1.6%) became negative (S1+/S4-) and 164 (66.7%) remained negative. The percentage of children becoming CMV positive was significantly (P<0.001) higher in day-care centers where more than 40 children were enrolled. Nine outbreaks due to respiratory syncytial virus, rhinovirus and enterovirus were recorded in 8 of 29 (27.6%) day-care centers. Viral acute respiratory infections were significantly (P<0.05) more frequently recorded in day-care centers in which CMV and respiratory viruses cocirculated and were significantly (P<0.001) more frequently reported in CMV-infected children. These findings suggest that viral acute respiratory infections are significantly more likely to occur in CMV-infected children.
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页码：167 / 172
页数：5
相关论文
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