Comparative transcriptomics and network pharmacology analysis to identify the potential mechanism of celastrol against osteoarthritis

[1] Oo WM(2018)Disease-modifying drugs in osteoarthritis: current understanding and future therapeutics Expert Opin Emerg Drugs 23 331-347

[2] Yu SP(2016)Disease-modifying treatments for osteoarthritis (DMOADs) of the knee and hip: lessons learned from failures and opportunities for the future Osteoarthr Cartil 24 2013-2021

[3] Daniel MS(2016)Control of autoimmune inflammation by celastrol, a natural triterpenoid Pathog Dis 74 ftw059-785

[4] Hunter DJ(2019)Treatment of neurodegenerative diseases with bioactive components of Tripterygium wilfordii Am J Chin Med 47 769-1011

[5] Karsdal MA(2015)Treatment of obesity with celastrol Cell 161 999-88

[6] Michaelis M(2018)Celastrol attenuates pain and cartilage damage via SDF-1/CXCR4 signalling pathway in osteoarthritis rats J Pharm Pharmacol 70 81-7

[7] Ladel C(2013)Celastrol, an inhibitor of heat shock protein 90beta potently suppresses the expression of matrix metalloproteinases, inducible nitric oxide synthase and cyclooxygenase-2 in primary human osteoarthritic chondrocytes Eur J Pharmacol 708 1-120

[8] Siebuhr AS(2018)What did we learn from ‘omics’ studies in osteoarthritis Curr Opin Rheumatol 30 114-690

[9] Bihlet AR(2008)Network pharmacology: the next paradigm in drug discovery Nat Chem Biol 4 682-2472

[10] Andersen JR(2009)Network analyses in systems pharmacology Bioinformatics 25 2466-W633

[1] Oo WM(2018)Disease-modifying drugs in osteoarthritis: current understanding and future therapeutics Expert Opin Emerg Drugs 23 331-347

[2] Yu SP(2016)Disease-modifying treatments for osteoarthritis (DMOADs) of the knee and hip: lessons learned from failures and opportunities for the future Osteoarthr Cartil 24 2013-2021

[3] Daniel MS(2016)Control of autoimmune inflammation by celastrol, a natural triterpenoid Pathog Dis 74 ftw059-785

[4] Hunter DJ(2019)Treatment of neurodegenerative diseases with bioactive components of Tripterygium wilfordii Am J Chin Med 47 769-1011

[5] Karsdal MA(2015)Treatment of obesity with celastrol Cell 161 999-88

[6] Michaelis M(2018)Celastrol attenuates pain and cartilage damage via SDF-1/CXCR4 signalling pathway in osteoarthritis rats J Pharm Pharmacol 70 81-7

[7] Ladel C(2013)Celastrol, an inhibitor of heat shock protein 90beta potently suppresses the expression of matrix metalloproteinases, inducible nitric oxide synthase and cyclooxygenase-2 in primary human osteoarthritic chondrocytes Eur J Pharmacol 708 1-120

[8] Siebuhr AS(2018)What did we learn from ‘omics’ studies in osteoarthritis Curr Opin Rheumatol 30 114-690

[9] Bihlet AR(2008)Network pharmacology: the next paradigm in drug discovery Nat Chem Biol 4 682-2472

[10] Andersen JR(2009)Network analyses in systems pharmacology Bioinformatics 25 2466-W633