Towards model-informed precision dosing of piperacillin: multicenter systematic external evaluation of pharmacokinetic models in critically ill adults with a focus on Bayesian forecasting

[1] Evans L(2021)Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 Crit Care Med 49 606-618

[2] Rhodes A(2007)Epidemiology of sepsis in Germany: results from a national prospective multicenter study Intensive Care Med 33 2235-2244

[3] Alhazzani W(2017)Time to treatment and mortality during mandated emergency care for sepsis N Engl J Med 376 1589-1596

[4] Engel C(2006)Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock Crit Care Med 34 2133-2140

[5] Brunkhorst FM(2015)Time to appropriate antibiotic therapy is an independent determinant of postinfection ICU and hospital lengths of stay in patients with sepsis Crit Care Med 43 1127-1153

[6] Bone H-G(2020)Antimicrobial therapeutic drug monitoring in critically ill adult patients: a Position Paper Intensive Care Med 46 840-851

[7] Seymour CW(2009)Pharmacokinetic issues for antibiotics in the critically ill patient Crit Care Med 37 R206-1112

[8] Gesten F(2011)Antibiotics in critically ill patients: a systematic review of the pharmacokinetics of β-lactams Crit Care 15 86-e802

[9] Prescott HC(2020)The higher the better? Defining the optimal beta-lactam target for critically ill patients to reach infection resolution and improve outcome J Intensive Care 8 1104-266

[10] Kumar A(2020)Towards precision medicine: therapeutic drug monitoring-guided dosing of vancomycin and β-lactam antibiotics to maximize effectiveness and minimize toxicity Am J Health Syst Pharm 77 e795-e2619

[1] Evans L(2021)Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 Crit Care Med 49 606-618

[2] Rhodes A(2007)Epidemiology of sepsis in Germany: results from a national prospective multicenter study Intensive Care Med 33 2235-2244

[3] Alhazzani W(2017)Time to treatment and mortality during mandated emergency care for sepsis N Engl J Med 376 1589-1596

[4] Engel C(2006)Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock Crit Care Med 34 2133-2140

[5] Brunkhorst FM(2015)Time to appropriate antibiotic therapy is an independent determinant of postinfection ICU and hospital lengths of stay in patients with sepsis Crit Care Med 43 1127-1153

[6] Bone H-G(2020)Antimicrobial therapeutic drug monitoring in critically ill adult patients: a Position Paper Intensive Care Med 46 840-851

[7] Seymour CW(2009)Pharmacokinetic issues for antibiotics in the critically ill patient Crit Care Med 37 R206-1112

[8] Gesten F(2011)Antibiotics in critically ill patients: a systematic review of the pharmacokinetics of β-lactams Crit Care 15 86-e802

[9] Prescott HC(2020)The higher the better? Defining the optimal beta-lactam target for critically ill patients to reach infection resolution and improve outcome J Intensive Care 8 1104-266

[10] Kumar A(2020)Towards precision medicine: therapeutic drug monitoring-guided dosing of vancomycin and β-lactam antibiotics to maximize effectiveness and minimize toxicity Am J Health Syst Pharm 77 e795-e2619