Histone monoubiquitination by Clock–Bmal1 complex marks Per1 and Per2 genes for circadian feedback

被引：0
作者：
Alfred G Tamayo
Hao A Duong
Maria S Robles
Matthias Mann
Charles J Weitz
机构：
[1] Harvard Medical School,Department of Neurobiology
[2] Max-Planck Institute of Biochemistry,Department of Proteomics and Signal Transduction
来源：
Nature Structural & Molecular Biology | 2015年 / 22卷
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摘要：
New data show that Clock–Bmal1, the central transcriptional activator that drives expression of circadian target genes, also recruits the Ddb1–Cullin-4 ubiquitin ligase to clock promoters to enhance the subsequent binding of the feedback repressors that generate the circadian periodicity of gene expression.
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页码：759 / 766
页数：7
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