Interaction of Oxidative Stress and the Clinical Course of Chronic Cerebral Ischemia

被引：1

作者：

Azizova O.A. ^{[1
]}

Solov’eva E.Y. ^{[2
]}

Aseichev A.V. ^{[1
]}

Baranova O.A. ^{[2
]}

Bekman E.M. ^{[1
]}

Karneev A.N. ^{[2
]}

Mironova O.M. ^{[2
]}

Manevskii A.P. ^{[2
]}

Ivanokov A.N. ^{[2
]}

Fedin A.I. ^{[2
]}

Sergienko V.I. ^{[1
]}

机构：

[1] Research Institute of Physicochemical Medicine, Federal Medical-Biological Agency, Moscow

[2] N. I. Pirogov Russian National Medical Research University, Moscow

来源：

Neuroscience and Behavioral Physiology | 2015年 / 45卷 / 1期

关键词：

chronic cerebral ischemia; oxidative stress; prognosis of disease course; stroke; transport function of albumin;

D O I：

10.1007/s11055-014-0038-8

中图分类号：

学科分类号：

摘要：

A total of 360 patients with different stage of chronic cerebral ischemia (CCI) were studied. Of these, 180 patients, observed for 12 months from initial assessment, were divided into two groups depending on the course of illness – favorable (stable) and unfavorable (progressive or with acute episodes of impaired cerebral circulation). Markers of oxidative stress were assessed in terms of the level of lipid (malondialdehyde) and protein (carbonyl protein oxidation products, plasma SH groups levels, and accumulation of advanced oxidation protein products (AOPP) in plasma. Along with measures of oxidative stress, the binding capacity of albumin was also determined, using the fluorescent probe K-35. Initial values for these markers were measured, along with concentrations after copper ion-induced oxidation of plasma. The greatest increases in measures of oxidative stress were seen in patients with acute episodes of circulatory failure. Significant differences were found in measures of oxidative stress in groups of patients with different clinical variants of the course of CCI and qualitative and quantitative diagnostic criteria suggesting an unfavorable course of illness and the risk of developing stroke were established. The ability to diagnose a prognostically unfavorable course of illness allows appropriate treatment to be started in a timely fashion. © 2014, Springer Science+Business Media New York.

引用

页码：36 / 41

页数：5

共 15 条

[1]

Gusev E.I., Skvortsova V.I., Cerebral Ischemia, Moscow, pp. 45-98, (2001)

[2]

Suslina Z.A., Fedorova T.N., Maksimova M.Y., Et al., Antioxidant therapy in ischemic stroke, Zh. Nevrol. Psikhiat, 100, pp. 34-38, (2000)

[3]

Fedin A.I., Rumyantseva S.A., O. R. Kuznetsov, V, (2004)

[4]

Boldyrev A.A., Oxidative stress and the brain, Soros. Obraz. Zh, 7, 4, pp. 21-28, (2001)

[5]

Dyumaev K.M., Voronin T.A., Smirnov L.D., Antioxidants in the Prophylaxis and Treatment of CNS Pathology, (1995)

[6]

Kotov S.V., Sidorova O.P., Isakova E.V., Use of thioctacid and cycloferon in the treatment of patients with ischemic stroke, Manual for Physicians, Moscow, (2003)

[7]

Spranger T., Finckh B., Fingerhut R., Et al., How different constituents of human plasma and low density lipoprotein determine plasma oxidizability by copper, Chem. Phys. Lipids, 91, 1, pp. 39-52, (1998)

[8]

Dubey A., Forster M.J., Shoal R.S., Effect of age and caloric intake on protein oxidation in different brain regions and on behavioral functions of the mouse, Arch. Biochem. Biophys, 333, 1, pp. 189-197, (1996)

[9]

Savchenkova A.P., Dudnik L.B., Solov'eva N.P., Azizova O.A., Kinetic patterns of Cu<sup>2+</sup>-induced plasma and serum lipid oxidation, Biomed. Khim, 6, pp. 576-587, (2003)

[10]

Levine R., Williams J.A., Stadman E.R., Shachter E., Carbonyl assays for determination of oxidatively modified proteins, Meth. Enzymol, 233, pp. 346-357, (1994)

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