Systematic Review and Meta-analysis of Pharmacological Treatment of the Symptoms of Attention-Deficit/Hyperactivity Disorder in Children with Pervasive Developmental Disorders

被引：0

作者：

Brian Reichow

Fred R. Volkmar

Michael H. Bloch

机构：

[1] Yale School of Medicine Child Study Center,

来源：

Journal of Autism and Developmental Disorders | 2013年 / 43卷

关键词：

Autism; Pervasive developmental disorder; Attention deficit/hyperactivity disorder; Methylphenidate; Meta-analysis; Atomoxetine; Clonidine; ADHD; ASD; Autism spectrum disorder; PDD; PDD-NOS;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Many children with pervasive developmental disorders (PDD) exhibit behaviors and symptoms of attention-deficit/hyperactivity disorder (ADHD). We sought to determine the relative efficacy of medications for treating ADHD symptoms in children with PDD by identifying all double-blind, randomized, placebo-controlled trials examining the efficacy of medications for treating ADHD symptoms in children with PDD. We located seven trials involving 225 children. A random effects meta-analysis of four methylphenidate trials showed methylphenidate to be effective for treating ADHD symptoms in children with PDD (ES = .67). Several adverse events were greater for children were taking methylphenidate compared to placebo. An individual trial of clonidine and two trials of atomoxetine suggest these agents may also be effective in treating ADHD symptoms in children with PDD.

引用

页码：2435 / 2441

页数：6

共 150 条

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