Metastasis of cervical cancer indicated by elevation of serum CA125 produced by mediastinal lymph nodes: a case report

被引：1

作者：

Honda, Ken-ichi ^{[1
]}

Miyama, Masato ^{[2
]}

Nishii, Yuko ^{[3
]}

Tasaka, Reiko ^{[4
]}

Nakano, Yusuke ^{[5
]}

Umesaki, Naohiko ^{[2
]}

Fukuda, Takeshi ^{[4
]}

Ichimura, Tomoyuki ^{[4
]}

Yasui, Tomoyo ^{[4
]}

Sumi, Toshiyuki ^{[4
]}

机构：

[1] PL Hosp, Dept Obstet & Gynecol, 2204 Shindou, Tondabayashi, Osaka 5848585, Japan

[2] Izumi City Gen Hosp, Dept Gynecol, Izumi, Japan

[3] MedCity21, Osaka, Japan

[4] Osaka Metropolitan Univ, Grad Sch Med, Dept Obstet & Gynecol, Osaka, Japan

[5] Izumi City Gen Hosp, Dept Oncol, Izumi, Japan

来源：

JOURNAL OF MEDICAL CASE REPORTS | 2024年 / 18卷 / 01期

关键词：

Cervical cancer; Biomarker; SCCA; CA125; Lymph nodes; SQUAMOUS-CELL CARCINOMA;

D O I：

10.1186/s13256-024-04417-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BackgroundIn patient assessment for recurrence of neoplasia, a biomarker that shows an elevated serum value before the first treatment is a candidate for follow-up examination. The biomarker squamous cell carcinoma antigen is usually utilized for follow-up of squamous cell cancer of the cervix.Case presentationWe herein report a 30-year-old Japanese woman of postoperative metastasis of cervical squamous cell cancer to the mediastinal and supraclavicular lymph nodes as indicated by an elevated serum cancer antigen 125 concentration and not by the squamous cell carcinoma antigen value. After chemoradiotherapy and chemotherapy, the serum cancer antigen 125 concentration decreased to a normal value. Squamous cell carcinoma antigen was found to be distributed in both the squamous cell cancer tissue of the cervix and the supraclavicular lymph node metastatic tissue. By contrast, cancer antigen 125 was distributed in the supraclavicular lymph node metastatic tissue but not in the original squamous cell cancer tissue of the cervix.ConclusionIn this case, metastasis of cervical cancer to the mediastinal and supraclavicular lymph nodes was shown by the biomarker cancer antigen 125, which was not present in the original neoplasia.

引用

页数：5

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