Age at onset of type 1 diabetes between puberty and 30 years old is associated with increased diabetic nephropathy risk

被引：0
作者：
Yen-Bo Lin
Tien-Jyun Chang
机构：
[1] National Taiwan University Hospital Bei-Hu Branch,Division of Endocrinology and Metabolism, Department of Internal Medicine
[2] National Taiwan University Hospital,Division of Endocrinology and Metabolism, Department of Internal Medicine
[3] National Taiwan University School of Medicine,Division of Endocrinology and Metabolism, Department of Internal Medicine
[4] Taichung Veterans General Hospital,Department of Internal Medicine, School of Medicine
[5] National Yang Ming Chiao Tung University,Section of Endocrinology and Metabolism, Department of Internal Medicine
[6] Taipei Veterans General Hospital,Institute of Medical Technology, College of Life Science
[7] National Chung-Hsing University,Tao
[8] National Health Research Institutes,Yuan General Hospital
[9] Ministry of Health and Welfare,Institute of Medicine
[10] Changhua County Public Health Bureau,Division of Endocrinology and Metabolism, Department of Internal Medicine
[11] Chung Shang Medical University,Division of Endocrinology and Metabolism, Department of Internal Medicine
[12] Chung Shang Medical University Hospital,Department of Internal Medicine, School of Medicine, College of Medicine
[13] Tri-Service General Hospital,Division of Endocrinology and Metabolism, Department of Internal Medicine
[14] National Cheng Kung University,Graduate Institute of Clinical Medicine
[15] National Cheng Kung University Hospital,undefined
[16] National Taiwan University College of Medicine,undefined
[17] Kaoshiung Chang Gung Memorial Hospital,undefined
[18] Yuanlin Christian Hospital,undefined
[19] Chiayi Chang Gung Memorial Hospital,undefined
[20] Linkou Chang Gung Memorial Hospital,undefined
[21] Changhua Christian Hospital,undefined
[22] SinLau Hospital,undefined
[23] Kaohsiung Veterans General Hospital,undefined
[24] Ditmanson Medical Foundation Chia-Yi Christian Hospital,undefined
[25] Lee Yau-Jiunn Clinic,undefined
[26] Far Eastern Memorial Hospital,undefined
[27] China Medical University Hospital,undefined
[28] MacKay Memorial Hospital,undefined
[29] Kaohsiung Medical University Chung-Ho Memorial Hospital,undefined
[30] Cheng Hsin General Hospital,undefined
[31] Samuel Chen Clinic,undefined
[32] Dr. Su Diabetes Clinic,undefined
[33] Feng-Yuan Hospital,undefined
[34] Ministry of Health and Welfare,undefined
[35] Taichung Hospital,undefined
[36] Ministry of Health and Welfare,undefined
[37] Liao Chung Chia Clinic,undefined
[38] Ansn Clinic,undefined
[39] Landseed Hospital,undefined
[40] Show Chwan Memorial Hospital,undefined
[41] Geng Sin Clinic,undefined
[42] Shigang District Public Health Center,undefined
[43] Cheng Ching Hospital,undefined
[44] Jing Pin Clinic,undefined
[45] Huang Hsin Yang Clinic,undefined
[46] Changhua Christian Hospital Yuan Branch,undefined
[47] Wei-Gong Memorial Hospital,undefined
[48] Neng-Chun Diabetes Clinic,undefined
[49] Neihu Cathay Clinic,undefined
[50] Da Chia Clinic,undefined
来源：
Scientific Reports | / 14卷
关键词：
Risk factors; Diabetic nephropathy; Type 1 diabetes; Onset age of type 1 diabetes; Puberty;
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学科分类号：
摘要：
Diabetic nephropathy is a critical complication of patients with type 1 diabetes, while epidemiological studies were scarce among Asian countries. We conducted a cross-sectional study to identify factors associated with diabetic nephropathy by questionnaires, using student’s t-test, chi-square test, and multivariable logistic regression. Among 898 participants, 16.7% had diabetic nephropathy. Compared with non-diabetic nephropathy patients, the patients with diabetic nephropathy had significantly higher percentage with onset age of type 1 diabetes between puberty and under 30 years old (female ≥ 12 or male ≥ 13 years old to 29 years old), longer diabetes duration, having family history of diabetes and diabetic nephropathy, accompanied with hypertension, hyperlipidemia, or coronary artery disease (CAD). Compared with patients with onset age before puberty, the odds of diabetic nephropathy occurrence increased to 1.61 times in patients with onset age between puberty and under 30 years old (p = 0.012) after adjusting diabetes duration. Age of diabetes onset between puberty and under 30 years old, diabetes duration, HbA1c, hospital admission within 3 years, diabetic retinopathy, hypertension, systolic blood pressure (SBP), triglyceride levels, and use of angiotensin converting enzyme inhibitor (ACEI) and/or angiotensin receptor blockers (ARB) were independent factors associated with diabetic nephropathy Screening for proteinuria is important in daily clinical practice and should be part of diabetes self-management education for patients with type 1 diabetes.
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