Cancer morbidity in psychiatric patients: influence of lithium carbonate treatment

被引：0
作者：
Y Cohen
A Chetrit
Y Cohen
P Sirota
B Modan
机构：
[1] Tel Aviv University Medical School,Geha Psychiatric Hospital
[2] Tel Aviv University Medical School,Department of Clinical Epidemiology, Chaim Sheba Medical Centre, The Stanley Steyer Institute for Cancer Epidemiology and Research
来源：
Medical Oncology | 1998年 / 15卷
关键词：
cancer; mental disorders; lithium; epidemiology;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The relationship between mental diseases and cancer development has been examined in a number of studies but the findings are still inconclusive and suffer from methodological problems. Studies conducted to examine the effect of lithium on malignant cells yielded inconsistent results. The study group included 609 patients treated by lithium carbonate and 2396 controls. A lower but non significant risk (RR=0.79; Cl=0.17–3.60) to develop nonepithelial tumors was found among lithium carbonate treated psychiatric patients as compared to controls. A significantly (P=0.05) inverse trend of cancer with lithium dose was observed. The risk of cancer development among each group of psychiatric patients was significantly lower than in the general population (RR=0.68 for the lithium treated group versus 0.78 for controls). Mental patients have a lower cancer prevalence than the general population and lithium may have a protective effect.
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页码：32 / 36
页数：4
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