Comparison of the rat dorsal and ventral striatopallidal system A study using the GABAA-receptor α1-subunit and parvalbumin immunolabelingA study using the GABAA-receptor α1-subunit and parvalbumin immunolabeling

被引：0

作者：

A. Riedel

W. Härtig

J.-M. Fritschy

G. Brückner

U. Seifert

K. Brauer

机构：

[1] Department of Neuroanatomy,

[2] Paul Flechsig Institute for Brain Research,undefined

[3] University of Leipzig,undefined

[4] Jahnallee 59,undefined

[5] D-04109 Leipzig,undefined

[6] Germany Fax: +49-341-2114492,undefined

[7] Department of Neurochemistry,undefined

[8] Paul Flechsig Institute for Brain Research,undefined

[9] University of Leipzig,undefined

[10] Jahnallee 59,undefined

[11] D-04109 Leipzig,undefined

[12] Germany,undefined

[13] Institute of Pharmacology,undefined

[14] University of Zürich,undefined

[15] Winterthurerstrasse 190,undefined

[16] CH-8057 Zurich,undefined

[17] Switzerland,undefined

来源：

Experimental Brain Research | 1998年 / 121卷

关键词：

Key words GABAA-receptor α1-subunit; Parvalbumin; Striatum; Pallidum; Rat;

D O I：

暂无

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学科分类号：

摘要：

The ventral striatum is more closely related to limbic brain regions than the dorsal striatum in spite of the remarkable similarities in the structural organization between these two brain regions. The present study is focused on the comparison of ventral striatopallidal territories and the dorsal striatopallidal system regarding the GABAA-receptor α1-subunit and parvalbumin immunoreactivity, as these markers showed specific distribution patterns and coexpression sites in the more intensely studied dorsal regions. Our investigations revealed that: (1) Parvalbumin single-labeled cells and a moderate number of neurons single-labeled with the GABAA-receptor α1-subunit exist not only in the dorsal but also in the ventral striatum, including the striatal cell bridges. In addition, morphologically similar neurons positive for the α1-subunit were also found in the corpus callosum and anterior commissure. (2) A small number of double-labeled neurons was seen not only in dorsal but also in ventral striatal regions. Such cells were mainly located near the border with the globus pallidus and ventral pallidum. They are likely to represent a further type of striatal neuron. (3) The vast majority of neurons in the entopeduncular nucleus, the homologue of the primate internal globus pallidus segment, coexpressed α1-subunit and parvalbumin immunoreactivity, as reported previously for the other pallidal compartments. (4) The islands of Calleja adjoining the ventral pallidal extensions in the olfactory tubercle exhibited a strong α1-subunit immunoreactivity in the neuropil as well as somata single- or double-labeled for both markers. Our findings indicate that the dorsal and ventral striatopallidal compartments are similarly organized in general with respect to the occurrence and distribution of single- and double-labeled parvalbumin-immunoreactive and GABAA-receptor α1-subunit-immunoreactive neurons.

引用

页码：215 / 221

页数：6