IP3 receptors in cell survival and apoptosis: Ca2+ release and beyond

被引：0
作者：
Suresh K. Joseph
György Hajnóczky
机构：
[1] Thomas Jefferson University,Department of Pathology & Cell Biology
来源：
Apoptosis | 2007年 / 12卷
关键词：
Apoptosis; Calcium; Endoplasmic reticulum; IP; IP; receptor; Mitochondria;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Inositol 1,4,5-trisphosphate receptors (IP3Rs) serve to discharge Ca2+ from ER stores in response to agonist stimulation. The present review summarizes the role of these receptors in models of Ca2+-dependent apoptosis. In particular we focus on the regulation of IP3Rs by caspase-3 cleavage, cytochrome c, anti-apoptotic proteins and Akt kinase. We also address the evidence that some of the effects of IP3Rs in apoptosis may be independent of their ion-channel function. The role of IP3Rs in delivering Ca2+ to the mitochondria is discussed from the perspective of the factors determining inter-organellar dynamics and the spatial proximity of mitochondria and ER membranes.
引用
收藏
页码：951 / 968
页数：17
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