Gastric gastrointestinal stromal tumor with synchronous metastasis to the esophagus: Case report and review of the literature

被引：0

作者：

Ishiguro Y. ^{[1
]}

Hosoya Y. ^{[1
]}

Hyodo M. ^{[1
]}

Saito S. ^{[1
]}

Lefor A. ^{[1
]}

Yasuda Y. ^{[1
]}

Nagai H. ^{[1
]}

Sakurai S. ^{[2
]}

机构：

[1] Department of Surgery, School of Medicine, Jichi Medical University, Shimotsuke, Tochigi 329-0498

[2] Department of Tumor Pathology, Graduate School of Medicine, Gunma University, Gunma

来源：

Esophagus | 2008年 / 5卷 / 4期

关键词：

Esophageal metastasis; Gastrointestinal stromal tumor;

D O I：

10.1007/s10388-008-0175-7

中图分类号：

学科分类号：

摘要：

We report a patient with synchronous gastrointestinal stromal tumors (GISTs) of the stomach and esophagus. The gastric GIST was larger than that in the esophagus, and no direct connection between the two lesions was seen microscopically. Based on molecular analysis, both lesions had the same c-kit mutation on exon 11, with deletion of codon 557-558. Analysis of normal gastric tissue showed no mutations. The gastric GIST was the primary lesion, and the esophageal tumor was thought to suggest a hematogenous metastasis. A liver metastasis in S6 appeared 6 months after surgery. Imatinib mesylate has been an effective treatment for liver metastasis at follow-up of 2 years. © 2008 Japan Esophageal Soceity and Springer.

引用

页码：219 / 223

页数：4

共 14 条

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