共 111 条
[1]
Lindsley CW(2010)The Akt/PKB family of protein kinases: a review of small molecule inhibitors and progress towards target validation: a 2009 update Curr Top Med Chem 10 458-477
[2]
Bellacosa A(2005)Activation of AKT kinases in cancer: implications for therapeutic targeting Adv Cancer Res 94 29-86
[3]
Kumar CC(2003)Radiation sensitization of human cancer cells in vivo by inhibiting the activity of PI3K using LY294002 Int J Radiat Oncol Biol Phys 56 846-853
[4]
Di Cristofano A(2003)HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells Oncogene 22 3205-3212
[5]
Testa JR(2013)Targeting the PI3K-AKT-mTOR signaling network in cancer Chin J Cancer 32 253-265
[6]
Gupta AK(2012)Preclinical pharmacology of AZD5363, an inhibitor of AKT: pharmacodynamics, antitumor activity, and correlation of monotherapy activity with genetic background Mol Cancer Ther 11 873-887
[7]
Cerniglia GJ(2004)Effect of iron deficiency anemia on the levels of hemoglobin A1c in nondiabetic patients Acta Haematol 112 126-128
[8]
Mick R(2014)Rapid induction of apoptosis by PI3K inhibitors is dependent upon their transient inhibition of RAS-ERK signaling Cancer Discov 4 334-347
[9]
Ahmed MS(2009)Mechanism and management of AKT inhibitor-induced hyperglycemia Clin Cancer Res 15 217-225
[10]
Bakanauskas VJ(2006)Chronic inhibition of mammalian target of rapamycin signaling downregulates insulin receptor substrates 1 and 2 and AKT activation: a crossroad between cancer and diabetes? J Am Soc Nephrol 17 2236-2244