Effect of a mitochondria-targeted antioxidant on ageing of Podospora anserina: Ultrastructural study

被引：0
|
作者：
Ojovan S.M. [1 ,2 ,4 ]
Bakeeva L.E. [2 ,4 ]
Shtaer O.V. [3 ]
Kamzolkina O.V. [3 ]
Vyssokikh M.Y. [2 ,4 ]
机构：
[1] Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University
[2] Belozersky Institute of Physico-chemical Biology, Lomonosov Moscow State University
[3] Biological Faculty, Lomonosov Moscow State University
[4] Mitoengineering Center, Lomonosov Moscow State University
来源：
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology | 2010年 / 4卷 / 1期
关键词：
Mitochondria ultrastructure; Mitochondria-targeted antioxidant SkQ[!sub]1[!/sub; Podospora anserina ultrastructure; Senescence;
D O I：
10.1134/S199074781001006X
中图分类号：
学科分类号：
摘要：
A beneficial effect of mitochondria targeted antioxidant (MTA) SkQ1 added to the culture medium on life span of Podospora anserina was revealed. As was shown earlier, optimal concentration was 400 nM. SkQ1 was shown to increase P. anserina life span 2.4 times, at the same time maintaining native cell ultrastructure: degradative alterations were not revealed. Significant reorganization of P. anserina cell ultrastructure was detected. These changes were not described earlier. The greatest structural changes proceeded in mitochondria. Specific character of these alterations suggests an essential role of oxidative stress in senescence of P. anserina. © 2010 Pleiades Publishing, Ltd.
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页码：38 / 42
页数：4
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