Protocol for German trial of Acyclovir and corticosteroids in Herpes-simplex-virus-encephalitis (GACHE): a multicenter, multinational, randomized, double-blind, placebo-controlled German, Austrian and Dutch trial [ISRCTN45122933]

被引:0
作者
Francisco Martinez-Torres
Sanjay Menon
Maria Pritsch
Norbert Victor
Ekkehart Jenetzky
Katrin Jensen
Eva Schielke
Erich Schmutzhard
Jan de Gans
Chin-Hee Chung
Steffen Luntz
Werner Hacke
Uta Meyding-Lamadé
机构
[1] University of Heidelberg,Department of Neurology
[2] Krankenhaus Nordwest,Department of Neurology
[3] University of Heidelberg Medical School,Institute for Medical Biometry and Informatics
[4] Vivantes Auguste-Viktoria-Klinikum,Department of Neurology
[5] University of Innsbruck,Department of Neurology
[6] University of Amsterdam,Department of Neurology, Academic Medical Center
[7] University of Heidelberg,Department of Internal Medicine VI, Clinical Pharmacology and Pharmacoepidemiology
[8] Coordination Center for Clinical Studies (KKS) Heidelberg,Current Address: Department of Internal Medicine, Division of Infectious Diseases University of Texas Southwestern Medical Center at Dallas
[9] U.S.A.Department of Neurology,undefined
[10] University of Heidelberg,undefined
来源
BMC Neurology | / 8卷
关键词
Acyclovir; Bacterial Meningitis; Glasgow Outcome Scale; Herpetical Keratitis; Sample Size Adjustment;
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  • [1] Raschilas F(2002)Outcome of and prognostic factors for herpes simplex virus encephalitis in adults: results of a multicenter study Clin Infect Dis 35 254-260
  • [2] Wolff M(1997)Herpes simplex encephalitis treated with acyclovir: diagnosis and long term outcome J Neurol Neurosurg Psychiatry 63 321-6
  • [3] Delatour F(2006)Incidence and pathogenesis of clinical relapse after herpes simplex encephalitis in adults J Neurol 253 163-170
  • [4] McGrath N(2002)Experimental herpes simplex virus encephalitis: inhibition of the expression of inducible nitric oxide synthase in mouse brain tissue Neuroscience Letters 318 21-24
  • [5] Anderson NE(2004)Increased presence of matrix metalloproteinases 2 and 9 in short- and long-term experimental herpes simplex virus encephalitis Neuroscience Letters 368 274-278
  • [6] Croxon NC(2005)Acute and long-term alteration of chemokine mRNA expression after anti-viral and anti-inflammatory treatment in herpes simplex virus encephalitis Neuroscience Letters 374 197-202
  • [7] Powell KF(1999)Herpes simplex virus encephalitis: chronic progressive cerebral MRI changes in patients despite good clinical recovery Clin Infect Dis 28 148-149
  • [8] Skoldenberg B(1999)Herpes simplex virus encephalitis: chronic progressive cerebral MRI changes despite good clinical recovery and low viral load – an experimental mouse study Europ J Neurol 6 531-538
  • [9] Aurelius E(1997)Quantitation of Herpes Simplex Virus Type 1 DNA in cells of cerebrospinal fluid of patients with herpes simplex virus encephalitis Neurology 48 1341-1346
  • [10] Hjalmarsson A(2000)Herpes simplex replication and dissemination is not increased by corticosteroid treatment in a rat model of focal Herpes encephalitis J Neurovirol 6 25-32