RNA recognition by the Vts1p SAM domain

被引：0
|
作者：
Philip E Johnson
Logan W Donaldson
机构：
[1] York University,Department of Chemistry
[2] York University,Department of Biology
来源：
Nature Structural & Molecular Biology | 2006年 / 13卷
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摘要：
The putative yeast post-transcriptional regulator Vts1p and its related protein Smaug, from Drosophila melanogaster, each use a sterile alpha motif (SAM) domain to bind an RNA hairpin termed the Smaug recognition element (SRE). Here, we present the NMR structures of the Vts1p–SRE complex and the free SRE. Structural highlights include the direct recognition of a guanine base and the formation or stabilization of a base pair in the SRE loop.
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页码：177 / 178
页数：1
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