Vaccines that stimulate T cell immunity to HIV-1: the next step

被引：0
作者：
Andrew J McMichael
Wayne C Koff
机构：
[1] Oxford University,Nuffield Department of Medicine
[2] International AIDS Vaccine Initiative,undefined
来源：
Nature Immunology | 2014年 / 15卷
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暂无
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摘要：
Recent findings in the SIV-monkey model provide new evidence that stimulating effective CD8+ T cell immunity could provide protection. McMichael and Koff explore the path forward for optimizing such responses in humans.
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页码：319 / 322
页数：3
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  • [1] Haynes BF(2013)Progress in HIV-1 vaccine development Curr. Opin. HIV AIDS 8 326-332
  • [2] McElrath MJ(2011)Role of immune mechanisms in induction of HIV-1 broadly neutralizing antibodies Curr. Opin. Immunol. 23 383-390
  • [3] Verkoczy L(2009)Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand N. Engl. J. Med. 361 2209-2220
  • [4] Kelsoe G(2012)Immune-correlates analysis of an HIV-1 vaccine efficacy trial N. Engl. J. Med. 366 1275-1286
  • [5] Moody MA(2010)The immune response during acute HIV-1 infection: clues for vaccine development Nat. Rev. Immunol. 10 11-23
  • [6] Haynes BF(2000)Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination Science 290 486-492
  • [7] Rerks-Ngarm S(2008)HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case-cohort analysis Lancet 372 1894-1905
  • [8] Haynes BF(2013)Efficacy trial of a DNA/rAd5 HIV-1 preventive vaccine N. Engl. J. Med. 369 2083-2092
  • [9] McMichael AJ(2011)Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine Nature 473 523-527
  • [10] Borrow P(2013)Immune clearance of highly pathogenic SIV infection Nature 502 100-104
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