Learning and extinction of a passive avoidance response in mice with high levels of predisposition to catalepsy

被引：6

作者：

Dubrovina N I. ^{[1
]}

Zinov'ev D.R. ^{[1
]}

Zinov'eva D.V. ^{[1
]}

Kulikov A.V. ^{[2
]}

机构：

[1] State Research Institute of Physiology, Siberian Branch, Russian Academy of Medical Sciences, Novosibirsk 630117

[2] Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk 630090

来源：

Neuroscience and Behavioral Physiology | 2009年 / 39卷 / 5期

关键词：

Catalepsy; Conditioned passive avoidance reaction; Depression; Extinction; Memory; Mice;

D O I：

10.1007/s11055-009-9152-4

中图分类号：

学科分类号：

摘要：

This report presents results obtained from comparative analysis of learning and the dynamics of extinction of a conditioned passive avoidance response in ASC mice, which were bred for a high level of predisposition to catalepsy, and in CBA and AKR mice. The following findings were obtained: 1) impairments to the extinction of the memory of fear represent an important symptom of depression in ASC mice; 2) extinction is delayed in CBA mice; and 3) new inhibitory learning occurs quickly in AKR mice. Prolonged retention of the fear memory in ASC mice appears to be related to increased anxiety on prolonged testing without a punishment. The deficit of inhibition of the fear reaction in ASC mice allows this strain to be regarded as a genetic model of depression. © 2009 Springer Science+Business Media, Inc.

引用

页码：475 / 480

页数：5

共 50 条

[1] Characteristics of extinction of a conditioned passive avoidance reflex in mice with different levels of anxiety
Dubrovina N.I.
Tomilenko R.A.
Neuroscience and Behavioral Physiology, 2007, 37 (1) : 27 - 32
[2] Effects of activation and blockade of NMDA receptors on the extinction of a conditioned passive avoidance response in mice with different levels of anxiety
Tomilenko R.A.
Dubrovina N.I.
Neuroscience and Behavioral Physiology, 2007, 37 (5) : 509 - 515
[3] Extinction of Passive Avoidance Response in Different Mouse Strains
Dubrovina, N. I.
Zinovyev, R.
Zinovyeva, D. V.
ZHURNAL VYSSHEI NERVNOI DEYATELNOSTI IMENI I P PAVLOVA, 2010, 60 (06) : 712 - 718
[4] Effect of GDNF on the Behavior of ASC Mice with High Hereditary Predisposition to Catalepsy
Semenova, A. A.
Bazovkina, D. V.
Tsybko, A. S.
Naumenko, V. S.
Popova, N. K.
ZHURNAL VYSSHEI NERVNOI DEYATELNOSTI IMENI I P PAVLOVA, 2013, 63 (04) : 495 - 501
[5] Training and extinction of passive avoidance in mice lacking monoamine oxidase A
Dubrovina, NI
Popova, NK
Gilinsky, MA
Tomilenko, RA
Seif, I
ZHURNAL VYSSHEI NERVNOI DEYATELNOSTI IMENI I P PAVLOVA, 2005, 55 (02) : 221 - 226
[6] THE EFFECTS OF CHRONIC AMPHETAMINE ADMINISTRATION ON THE ACQUISITION AND EXTINCTION OF AN ACTIVE AND PASSIVE-AVOIDANCE RESPONSE IN MICE
KOKKINIDIS, L
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1983, 19 (04) : 593 - 598
[7] EXTINCTION OF A PASSIVE-AVOIDANCE RESPONSE IN ADRENALECTOMIZED AND DEMEDULLATED RATS
SILVA, MTA
BEHAVIORAL BIOLOGY, 1973, 9 (05): : 553 - 562
[8] Effects of Activation and Blockade of Dopamine Receptors on Extinction of Passive Avoidance Response in Mice with Depressive-Like State
Dubrovina, N. I.
Zinovyeva, D. V.
ZHURNAL VYSSHEI NERVNOI DEYATELNOSTI IMENI I P PAVLOVA, 2008, 58 (05) : 605 - 610
[9] PASSIVE AVOIDANCE LEARNING IN RATS, MICE, GERBILS, AND HAMSTERS
WALTERS, GC
ABEL, EL
PSYCHONOMIC SCIENCE, 1971, 22 (05): : 269 - 270
[10] Anseculin improves passive avoidance learning of aged mice
Knauber, J
Müller, WE
PHARMACOLOGICAL RESEARCH, 2003, 47 (03) : 225 - 233

← 1 2 3 4 5 →