Insulin allergy and resistance successfully treated by desensitisation with Aspart insulin

被引：32

作者：

Matheu V. ^{[1
]}

Perez E. ^{[2
]}

Hernández M. ^{[3
]}

Díaz E. ^{[2
]}

Darias R. ^{[4
]}

González A. ^{[4
]}

García J.C. ^{[2
]}

Sánchez I. ^{[2
]}

Feliciano L. ^{[5
]}

Caballero A. ^{[3
]}

de la Torre F. ^{[2
]}

机构：

[1] Medical Inflammation Research, Lund University, Lund

[2] Allergy Service, Hospital Universitario NS Candelaria

[3] Endocrinology Service, Hospital Universitario de Canarias

[4] Endocrinology Service, Hospital Universitario NS Candelaria

[5] Dermatology Service, Hospital Universitario NS Candelaria

来源：

Clinical and Molecular Allergy | / 3卷 / 1期

关键词：

Skin Test; Human Insulin; Protamine; Skin Prick Test; Insulin Analog;

D O I：

10.1186/1476-7961-3-16

中图分类号：

学科分类号：

摘要：

A 25-year-old, with type I Diabetes Mellitus with a previous diagnosis of Protamine Allergy but not to human Insulin, started to notice anaphylactic reactions inmmediatly after bolus with Insulin. Skin prick and intradermal test were positive to all insulins. Skin tests to other potential allergens resulted negative. Examination after bolus of Human Insulin revealed urticaria. Daily insulin requirement were around 2-2,4 U/Kg/day. Slow desensitisation with Aspart insulin, the insulin with lowest size of skin test, was performed using subcutaneous insulin pump. Six months after the end of desensitisation his daily insulin requirement decreased to 0.8 U/Kg/day and oral corticosteroids are being reduced with no symptoms. © 2005 Matheu et al., licensee BioMed Central Ltd.

引用

页数：18

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