Efficacy of increased-dose erlotinib for central nervous system metastases in non-small cell lung cancer patients with epidermal growth factor receptor mutation

被引:0
作者
Yosuke Togashi
Katsuhiro Masago
Masahide Fukudo
Yasuhiro Tsuchido
Chiyuki Okuda
Young Hak Kim
Yasuaki Ikemi
Yuichi Sakamori
Tadashi Mio
Toshiya Katsura
Michiaki Mishima
机构
[1] Kyoto University,Department of Respiratory Medicine, Graduate School of Medicine
[2] Kyoto University,Department of Pharmacy, Graduate School of Medicine
来源
Cancer Chemotherapy and Pharmacology | 2011年 / 68卷
关键词
Non-small cell lung cancer; Epidermal growth factor receptor; Tyrosine kinase inhibitor; Erlotinib; Central nervous system metastasis; Cerebrospinal fluid;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:1089 / 1092
页数:3
相关论文
共 109 条
[1]  
Paez JG(2004)EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy Science 304 1497-1500
[2]  
Jänne PA(2004)Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib N Engl J Med 350 2129-2139
[3]  
Lee JC(2005)High incidence of disease recurrence in the brain and leptomeninges in patients with nonsmall cell lung carcinoma after response to gefitinib Cancer 103 2344-2348
[4]  
Tracy S(2010)Frequent central nervous system failure after clinical benefit with epidermal growth factor receptor tyrosine kinase inhibitors in Korean patients with nonsmall-cell lung cancer Cancer 116 1336-1343
[5]  
Greulich H(2006)Response and resistance in a non-small-cell lung cancer patient with an epidermal growth factor receptor mutation and leptomeningeal metastases treated with high-dose gefitinib J Clin Oncol 24 4517-4520
[6]  
Gabriel S(2009)Efficacy of erlotinib for brain and leptomeningeal metastases in patients with lung adenocarcinoma who showed initial good response to gefitinib J Thorac Oncol 4 1415-1419
[7]  
Herman P(2009)Carcinomatous meningitis in non-small-cell lung cancer: response to high-dose erlotinib J Clin Oncol 27 31-32
[8]  
Kaye FJ(2010)High dose weekly erlotinib achieves therapeutic concentrations in CSF and is effective in leptomeningeal metastases from epidermal growth factor receptor mutant lung cancer J Neurooncol 99 283-286
[9]  
Lindeman N(2011)High-dose erlotinib for refractory brain metastases in a patient with relapsed non-small cell lung cancer J Thorac Oncol 6 653-654
[10]  
Boggon TJ(2010)Cerebrospinal fluid concentration of erlotinib and its active metabolite OSI-420 in patients with central nervous system metastases of non-small cell lung cancer J Thorac Oncol 5 950-955