Role of Thromboelastography Versus Coagulation Screen as a Safety Predictor in Pre-eclampsia/Eclampsia Patients Undergoing Lower-Segment Caesarean Section in Regional Anaesthesia

被引：11
作者：
Ahmad A. [1 ]
Kohli M. [2 ]
Malik A. [2 ]
Kohli M. [2 ]
Bogra J. [2 ]
Abbas H. [2 ]
Gupta R. [2 ]
Kushwaha B.B. [2 ]
机构：
[1] Department of Anesthesiology and Critical Care, T. S. Mishra Medical College and Hospital, Haleem Manor, Flat No.-401, 179/19, Baroodkhana, Golaganj, Lucknow
[2] Department of Anesthesiology and Critical Care, King George’s Medical University, Lucknow
[3] Department of Anesthesiology and Intensive Care, Maulana Azad Medical College, New Delhi
来源：
The Journal of Obstetrics and Gynecology of India | 2016年 / 66卷 / Suppl 1期
基金：
澳大利亚研究理事会; 英国惠康基金; 英国医学研究理事会;
关键词：
Coagulation; Regional anaesthesia; Thromboelastography;
D O I：
10.1007/s13224-016-0906-y
中图分类号：
学科分类号：
摘要：
Purpose: In this study, we aimed to correlate thromboelastography (TEG) variables versus conventional coagulation profile in all patients presenting with pre-eclampsia/eclampsia and to see whether TEG would be helpful for evaluating coagulation in parturients before regional anaesthesia. Materials and Methods: This was a prospective study on 100 pre-eclampsia/eclampsia patients undergoing lower-segment caesarean section under regional anaesthesia. Two blood samples were collected. First sample was used for TEG measurement and second sample for laboratory tests. The following TEG data were obtained—reaction time, kinetic time, alpha angle, and maximum amplitude (MA). The following laboratory tests were obtained—haematology (haemoglobin, TLC, DLC, platelet count) and coagulation test [prothrombin time (PT), activated partial thromboplastin time (aPTT), thrombin time (TT)]. Result: Out of 100 patients enrolled in the study, 80 (80 %) had a normal coagulation profile, while remaining 20 (20 %) had hypocoagulation profile. The results show that TEG parameters have a good correlation with conventional coagulation profile and also showed excellent independent predictive efficacy for prediction of hypocoagulation. PT, aPTT, and TT were directly proportional to R-time and K-time and inversely proportional to alpha angle (p < 0.001). Platelet count showed a strong positive correlation with MA (p < 0.001). Conclusion: By giving a global picture of haemostasis, TEG can lead to improved decision-making about safety of using regional anaesthesia. Its fast feedback time makes it ideal for monitoring in a fast moving situation such as in obstetric emergency. © 2016, Federation of Obstetric & Gynecological Societies of India.
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页码：340 / 346
页数：6
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