The significance of heat shock proteins in breast cancer therapy

被引：0
作者：
Sevil Oskay Halacli
Burcin Halacli
Kadri Altundag
机构：
[1] Hacettepe University Cancer Institute,Department of Medical Oncology
来源：
Medical Oncology | 2013年 / 30卷
关键词：
Heat shock proteins; Breast cancer; Treatment;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The evalutionary conserved heat shock proteins are involved basically life protecting mechanisms against harmful extracellular effects such as primarily heat shock response. Normally, the expression of these proteins is increased for cellular adaptation to high temperature. This increase is also important in the etiology of breast cancer. Overexpression of heat shock proteins is associated with reduced disease-free survival in breast cancer. However, increased expression of these proteins is related to acquired resistance of traditional chemotherapeutic drugs in use in breast cancer treatment. In this review, we discuss the multiple roles of heatshock proteins in resistance and where we are to overcome this in clinical practice.
引用
收藏
相关论文
共 82 条
[1]  
Ciocca DR(2005)Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications Cell Stress Chaperones 10 86-103
[2]  
Calderwood SK(1993)Role of the major heat shock proteins as molecular chaperones Annu Rev Cell Biol 9 601-634
[3]  
Georgopoulos C(1991)Heat shock, stress proteins, chaperones, and proteotoxicity Cell 66 191-197
[4]  
Welch WJ(1992)Protein folding in the cell Nature 355 33-45
[5]  
Hightower LE(1998)Protein folding in the cytosol: chaperonin-dependent and -independent mechanisms Trends Biochem Sci 23 68-73
[6]  
Gething MJ(2002)Disassembly of transcriptional regulatory complexes by molecular chaperones Science 296 2232-2235
[7]  
Sambrook J(2002)Hsp90 as a capacitor of phenotypic variation Nature 417 618-624
[8]  
Netzer WJ(2005)HSP90 and the chaperoning of cancer Nat Rev Cancer 5 761-772
[9]  
Hartl FU(2004)Increased risk of malignant progression in benign proliferating breast lesions defined by expression of heat shock protein 27 Br J Cancer 90 182-188
[10]  
Freeman BC(2011)Heat shock protein as molecular targets for breast cancer therapeutics J Breast Cancer 14 167-174
123456789