TCR-induced sumoylation of the kinase PKC-θ controls T cell synapse organization and T cell activation

被引：0
|
作者：
Xu-Dong Wang
Yu Gong
Zhi-Long Chen
Bei-Ni Gong
Ji-Ji Xie
Chuan-Qi Zhong
Qi-Long Wang
Liang-Hui Diao
Anlong Xu
Jiahuai Han
Amnon Altman
Yingqiu Li
机构：
[1] State Key Laboratory of Biocontrol,Division of Cell Biology
[2] Key Laboratory of Gene Engineering of the Ministry of Education,undefined
[3] School of Life Sciences,undefined
[4] Sun Yat-sen University,undefined
[5] La Jolla Institute for Allergy and Immunology,undefined
[6] State Key Laboratory of Cellular Stress Biology,undefined
[7] School of Life Sciences,undefined
[8] Xiamen University,undefined
来源：
Nature Immunology | 2015年 / 16卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Sumoylation regulates many cellular processes, but its role in TCR signaling remains unknown. Li and colleagues show that sumoylation of the kinase PKC-θ is required for the assembly of a mature immunological synapse.
引用
收藏
页码：1195 / 1203
页数：8
相关论文
共 50 条
  • [1] TCR-induced sumoylation of the kinase PKC-θ controls T cell synapse organization and T cell activation
    Wang, Xu-Dong
    Gong, Yu
    Chen, Zhi-Long
    Gong, Bei-Ni
    Xie, Ji-Ji
    Zhong, Chuan-Qi
    Wang, Qi-Long
    Diao, Liang-Hui
    Xu, Anlong
    Han, Jiahuai
    Altman, Amnon
    Li, Yingqiu
    NATURE IMMUNOLOGY, 2015, 16 (11) : 1195 - 1203
  • [2] Functional interaction between Vav and PKCθ is required for TCR-induced T cell activation
    Villalba, M
    Altman, A
    FASEB JOURNAL, 2000, 14 (06): : A1175 - A1175
  • [3] PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes
    Zuoming Sun
    Christopher W. Arendt
    Wilfried Ellmeier
    Edward M. Schaeffer
    Mary Jean Sunshine
    Leena Gandhi
    Justin Annes
    Daniela Petrzilka
    Abraham Kupfer
    Pamela L. Schwartzberg
    Dan R. Littman
    Nature, 2000, 404 : 402 - 407
  • [4] PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes
    Sun, ZM
    Arendt, CW
    Ellmeier, W
    Schaeffer, EM
    Sunshine, MJ
    Gandhi, L
    Annes, J
    Petrzilka, D
    Kupfer, A
    Schwartzberg, PL
    Littman, DR
    NATURE, 2000, 404 (6776) : 402 - 407
  • [5] A novel functional interaction between Vav and PKCθ is required for TCR-induced T cell activation
    Villalba, M
    Coudronniere, N
    Deckert, M
    Teixeiro, E
    Mas, P
    Altman, A
    IMMUNITY, 2000, 12 (02) : 151 - 160
  • [6] SELECTIVE-INHIBITION OF TCR-INDUCED T-CELL ACTIVATION BY 2 NOVEL TYROSINE KINASE INHIBITORS
    HANKE, JH
    GARDNER, JP
    WACHTMAN, T
    DOW, R
    CONNELLY, PA
    FASEB JOURNAL, 1995, 9 (03): : A235 - A235
  • [7] The Immunological Synapse, TCR Microclusters, and T Cell Activation
    Yokosuka, Tadashi
    Saito, Takashi
    IMMUNOLOGICAL SYNAPSE, 2010, 340 : 81 - 107
  • [8] Ubiquitin-Editing Enzyme A20 Restricts TCR-Induced T Cell Activation
    Oshima, Shigeru
    Ma, Averil
    Watanabe, Mamoru
    DIGESTIVE DISEASES AND SCIENCES, 2012, 57 (11) : 2728 - 2729
  • [9] Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis
    Tom Sidwell
    Yang Liao
    Alexandra L. Garnham
    Ajithkumar Vasanthakumar
    Renee Gloury
    Jonas Blume
    Peggy P. Teh
    David Chisanga
    Christoph Thelemann
    Fabian de Labastida Rivera
    Christian R. Engwerda
    Lynn Corcoran
    Kohei Kometani
    Tomohiro Kurosaki
    Gordon K. Smyth
    Wei Shi
    Axel Kallies
    Nature Communications, 11
  • [10] Antigen-induced translocation of PKC-θ to membrane rafts is required for T cell activation
    Bi, K
    Tanaka, Y
    Coudronniere, N
    Sugie, K
    Hong, SJ
    van Stipdonk, MJB
    Altman, A
    NATURE IMMUNOLOGY, 2001, 2 (06) : 556 - 563
12345