Endothelial Vesicles in the Blood–Brain Barrier: Are They Related to Permeability?

被引：0
作者：
Patricia A. Stewart
机构：
[1] University of Toronto,Division of Anatomy, Department of Surgery
来源：
Cellular and Molecular Neurobiology | 2000年 / 20卷
关键词：
blood–brain barrier; endothelium; vascular permeability; transcytosis; plasmalemmal vesicles; review;
D O I：
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学科分类号：
摘要：
1. Macromolecules cross capillary walls via large vascular pores that are thought to be formed by plasmalemmal vesicles. Early hypotheses suggested that vesicles transferred plasma constituents across the endothelial wall either by a “shuttle” mechanism or by fusing to form transient patent channels for diffusion. Recent evidence shows that the transcytotic pathway involves both movement of vesicles within the cell and a series of fusions and fissions of the vesicular and cellular membranes.
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页码：149 / 163
页数：14
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