Candidate Biomarkers in Children with Autism Spectrum Disorder: A Review of MRI Studies

被引：0
作者：
Dongyun Li
Hans-Otto Karnath
Xiu Xu
机构：
[1] Children’s Hospital of Fudan University,Division of Child Health Care
[2] University of Tübingen,Division of Neuropsychology, Center of Neurology, Hertie Institute of Clinical Brain Research
[3] University of South Carolina,Department of Psychology
来源：
Neuroscience Bulletin | 2017年 / 33卷
关键词：
Autism spectrum disorder; Biomarker; Neuroimaging; Structural MRI; Diffusion tensor imaging; Resting-state functional MRI; Magnetic resonance spectroscopy; Children; Human;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Searching for effective biomarkers is one of the most challenging tasks in the research field of Autism Spectrum Disorder (ASD). Magnetic resonance imaging (MRI) provides a non-invasive and powerful tool for investigating changes in the structure, function, maturation, connectivity, and metabolism of the brain of children with ASD. Here, we review the more recent MRI studies in young children with ASD, aiming to provide candidate biomarkers for the diagnosis of childhood ASD. The review covers structural imaging methods, diffusion tensor imaging, resting-state functional MRI, and magnetic resonance spectroscopy. Future advances in neuroimaging techniques, as well as cross-disciplinary studies and large-scale collaborations will be needed for an integrated approach linking neuroimaging, genetics, and phenotypic data to allow the discovery of new, effective biomarkers.
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页码：219 / 237
页数：18
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