Evidence that variation at the serotonin transporter gene influences susceptibility to attention deficit hyperactivity disorder (ADHD): analysis and pooled analysis

被引：0
作者：
L Kent
U Doerry
E Hardy
R Parmar
K Gingell
Z Hawi
A Kirley
N Lowe
M Fitzgerald
M Gill
N Craddock
机构：
[1] Molecular Psychiatry Group,Division of Neuroscience
[2] University of Birmingham,Departments of Psychiatry and Genetics
[3] Birmingham Childrens Hospital NHS Trust,undefined
[4] South Warwickshire Combined Care NHS Trust,undefined
[5] Dudley Priority Health NHS Trust,undefined
[6] Trinity College,undefined
来源：
Molecular Psychiatry | 2002年 / 7卷
关键词：
ADHD; 5HTT; hSERT; association study;
D O I：
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学科分类号：
摘要：
Reduced central serotonergic activity has been implicated in poor impulse regulation and aggressive behaviour in animals, adults and also young children.1,2 Two recently published studies have implicated variation at a polymorphism in the promoter of the serotonin transporter (5HTT; hSERT) in influencing susceptibility to ADHD.3,4 Consistent with these results we have also found a trend for the long allele of the promoter polymorphism to influence susceptibility to ADHD in a sample of 113 ADHD parent proband trios (65 transmissions vs 49 non-transmissions, χ2 = 2.25, P = 0.13). A pooled analysis of our, and these published results demonstrated a significant over representation of the long allele of the promoter in ADHD probands compared to controls (χ2 = 7.14, P = 0.008). We have also examined two other 5HTT polymorphisms (the VNTR in intron 2 and the 3′ UTR SNP). TDT analysis demonstrated preferential transmission of the T allele of the 3′ UTR SNP (χ2 = 4.06, P = 0.04). In addition, ETDT analysis of haplotypes demonstrated significant preferential transmission of haplotypes containing the T allele of the 3′ UTR SNP with the long allele of the promoter polymorphism (χ2 = 13.18, 3 df, P = 0.004) and the 10 repeat of the VNTR (χ2 = 8.77, 3 df, P = 0.03). This study provides further evidence for the possible involvement of the serotonin transporter in susceptibility to ADHD.
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页码：908 / 912
页数：4
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  • [11] Manor I(1994)Organisation of the human serotonin transporter gene J Neural Transm 95 157-162
  • [12] Eisenberg J(1996)Polymorphism in serotonin transporter gene associated with susceptibility to major depression Lancet 347 731-733
  • [13] Tyano S(1999)Presence of multiple polyadenylation signals and a single nucleotide polymorphism in the 3′ untranslated region of the human serotonin transporter gene J Neurochem 72 1384-1388
  • [14] Sever Y(1996)Association of anxiety related traits with a polymorphism in the serotonin transporter gene regulatory region Science 274 1527-1531
  • [15] Cohen H(1999)A serotonin transporter gene intron 2 polymorphic region, correlated with affective disorders, has allele-dependent differential enhancer-like properties in the mouse embryo Proc Natl Acad Sci USA 96 15251-15255
  • [16] Ebstein RP(2000)Variation at the serotonin transporter gene influences susceptibility to bipolar affective puerperal psychosis Lancet 356 1490-1491
  • [17] Swanson JM(1993)Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM) Am J Hum Genet 52 506-516
  • [18] Sergeant JA(1995)An extended transmission/disequilibrium test (TDT) for multi-allele marker loci Ann Hum Genet 59 323-336
  • [19] Taylor E(2000)Unbiased application of the transmission/disequilibrium test to multilocus haplotypes Am J Hum Genet 66 2009-2012
  • [20] Sonuga-Barke EJS(1987)Haplotype relative risks: an easy reliable way to construct a proper control sample for risk calculations Ann Hum Genet, 51 227-233
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