Localization of DJ-1 protein in the murine brain

被引：0
作者：
N. Kotaria
U. Hinz
S. Zechel
O. von Bohlen und Halbach
机构：
[1] Georgian Academy of Sciences,Institute of Physiology, Chemical Neuroanatomy
[2] University of Heidelberg,Interdisciplinary Center for Neurosciences (IZN), Department of Neuroanatomy
来源：
Cell and Tissue Research | 2005年 / 322卷
关键词：
DJ-1; CNS; Immunohistochemistry; Mouse (C57/BL6);
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Mutations in the DJ-1 gene have been identified to cause Parkinson's disease. In humans, nonmutated DJ-1 is expressed in specific brain areas but seems to be expressed by astrocytes rather than by neurons. In contrast, DJ-1 mRNA is mainly found in neurons in the mouse brain. We have investigated the distribution of DJ-1 protein in the mouse brain and found that DJ-1 protein is predominantly expressed by neurons but can also be detected in astrocytes. Consistent with a global role of DJ-1 in the brain, we found immunoreactivity, for example, in cortical areas, hippocampus, basolateral amygdala, the reticular nucleus of the thalamus, zona incerta, and locus coeruleus. Within the substantia nigra, however, DJ-1 is localized in both neuronal and nonneuronal cells, suggesting a distinct role in this area.
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页码：503 / 507
页数：4
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