Temporal dynamics of the multi-omic response to endurance exercise training

被引：85

作者：

Amar, David ^{[1
]}

Gay, Nicole R. ^{[2
]}

Jean-Beltran, Pierre M. ^{[3
]}

Bae, Dam ^{[4
]}

Dasari, Surendra ^{[5
]}

Dennis, Courtney ^{[6
]}

Evans, Charles R. ^{[7
]}

Gaul, David A. ^{[8
]}

Ilkayeva, Olga ^{[9
,10
]}

Ivanova, Anna A. ^{[11
]}

Kachman, Maureen T. ^{[12
]}

Keshishian, Hasmik ^{[3
]}

Lanza, Ian R. ^{[13
]}

Lira, Ana C. ^{[4
]}

Muehlbauer, Michael J. ^{[10
]}

Nair, Venugopalan D. ^{[14
]}

Piehowski, Paul D. ^{[15
]}

Rooney, Jessica L. ^{[16
]}

Smith, Kevin S. ^{[17
]}

Stowe, Cynthia L. ^{[18
]}

Zhao, Bingqing ^{[2
]}

Clark, Natalie M. ^{[3
]}

Jimenez-Morales, David ^{[1
]}

Lindholm, Malene E. ^{[1
]}

Many, Gina M. ^{[19
]}

Sanford, James A. ^{[19
]}

Smith, Gregory R. ^{[14
]}

Vetr, Nikolai G. ^{[17
]}

Zhang, Tiantian ^{[20
]}

Armenteros, Jose J. Almagro ^{[2
]}

Avila-Pacheco, Julian ^{[6
]}

Bararpou, Nasim ^{[2
]}

Ge, Yongchao ^{[14
]}

Hou, Zhenxin ^{[20
]}

Marwaha, Shruti ^{[1
]}

Presby, David M. ^{[21
]}

Raja, Archana Natarajan ^{[1
]}

Savage, Evan M. ^{[8
]}

Steep, Alec ^{[22
]}

Sun, Yifei ^{[23
,24
]}

Wu, Si ^{[2
]}

Zhen, Jimmy ^{[1
]}

Bodine, Sue C. ^{[4
,25
]}

Esser, Karyn A. ^{[26
]}

Goodyear, Laurie J. ^{[21
]}

Schenk, Simon ^{[27
]}

Montgomery, Stephen B. ^{[2
,17
,28
]}

Fernandez, Facundo M. ^{[8
]}

Sealfon, Stuart C. ^{[14
]}

Snyder, Michael P. ^{[2
]}

机构：

[1] Stanford Univ, Dept Med, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Genet, Stanford, CA 94305 USA

[3] Broad Inst MIT & Harvard, Prote Platform, Cambridge, MA 02142 USA

[4] Univ Iowa, Dept Internal Med, Iowa City, IA 52242 USA

[5] Mayo Clin, Dept Quantitat Hlth Sci, Rochester, MN USA

[6] Broad Inst MIT & Harvard, Metabol Platform, Cambridge, MA USA

[7] Univ Michigan, Dept Internal Med, Ann Arbor, MI USA

[8] Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA USA

[9] Duke Univ, Dept Med, Durham, NC USA

[10] Duke Univ, Duke Mol Physiol Inst, Durham, NC USA

[11] Emory Univ, Emory Integrated Metabol & Lipid Core, Atlanta, GA USA

[12] Univ Michigan, BRCF Metabol Core, Ann Arbor, MI USA

[13] Mayo Clin, Div Endocrinol Nutr & Metab, Rochester, MN USA

[14] Icahn Sch Med Mt Sinai, Dept Neurol, New York, NY USA

[15] Pacific Northwest Natl Lab, Environm Mol Sci Div, Richland, WA USA

[16] Univ Vermont, Dept Pathol & Lab Med, Burlington, VT USA

[17] Stanford Univ, Dept Pathol, Stanford, CA 94305 USA

[18] Wake Forest Sch Med, Dept Biostat & Data Sci, Winston Salem, NC USA

[19] Pacific Northwest Natl Lab, Div Biol Sci, Richland, WA USA

[20] Emory Univ, Dept Biochem, Atlanta, GA USA

[21] Joslin Diabet Ctr, Sect Integrat Physiol & Metab, Boston, MA USA

[22] Univ Michigan, Dept Human Genet, Ann Arbor, MI USA

[23] Icahn Sch Med Mt Sinai, Dept Pharmacol Sci, New York, NY USA

[24] Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY USA

[25] Oklahoma Med Res Fdn, Aging & Metab Res Program, Oklahoma City, OK 73104 USA

[26] Univ Florida, Dept Physiol & Aging, Gainesville, FL 32611 USA

[27] Univ Calif San Diego, Sch Med, Dept Orthopaed Surg, San Diego, CA 92093 USA

[28] Stanford Univ, Dept Biomed Data Sci, Stanford, CA 94305 USA

[29] Univ Alabama Birmingham, Dept Biostat, Birmingham, AL USA

[30] Beth Israel Deaconess Med Ctr, Div Cardiovasc Med, Boston, MA USA

[31] Wake Forest Univ Sch Med, Div Publ Hlth Sci, Winston Salem, NC USA

[32] Mayo Clin, Dept Med, Rochester, MN USA

[33] Stanford Univ, Dept Stat, Stanford, CA USA

[34] Stanford Univ, Dept Biomed Data Sci, Stanford, CA USA

[35] Univ Florida, Dept Aging & Geriatr Res, Gainesville, FL USA

[36] Wake Forest Univ Sch Med, Sect Gerontol & Geriatr Med, Winston Salem, NC USA

[37] Wake Forest Univ Sch Med, Dept Hlth & Exercise Sci, Winston Salem, NC USA

[38] Natl Inst Hlth, Natl Inst Aging, Bethesda, MD USA

[39] Natl Inst Diabet & Digest & Kidney Dis, Natl Inst Hlth, Bethesda, MD USA

[40] Univ Florida, Appl Physiol & Kinesiol, Gainesville, FL USA

[41] Univ Missouri, Dept Biomed Sci, Columbia, MO USA

[42] Univ Missouri, Dept Med Pharmacol & Physiol, Columbia, MO USA

[43] Univ Missouri, Dept Nutr & Exercise Physiol, Columbia, MO USA

[44] Univ Missouri, Dalton Cardiovasc Res Ctr, Columbia, MO USA

[45] Univ Texas, Dept Kinesiol & Hlth Educ, Austin, TX USA

[46] Univ Calif Los Angeles, Div Endocrinol & Diabet, Dept Med, Los Angeles, CA USA

[47] Univ Virginia, Ctr Publ Hlth Genom, Sch Med, Charlottesville, VA USA

[48] Joslin Diabet Ctr, Sect Clin Behav & Outcomes Res, Boston, MA USA

[49] Vanderbilt Univ, Dept Mol Physiol & Biophys, Nashville, TN USA

[50] Stetson Univ, Dept Hlth Sci, Deland, FL USA

来源：

NATURE | 2024年 / 629卷 / 8010期

基金：

美国国家科学基金会;

关键词：

PHYSICAL-ACTIVITY; SKELETAL-MUSCLE; ALL-CAUSE; ASSOCIATION; METABOLISM; MECHANISMS; KALLIKREIN; MORTALITY;

D O I：

10.1038/s41586-023-06877-w

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Regular exercise promotes whole-body health and prevents disease, but the underlying molecular mechanisms are incompletely understood 1-3 . Here, the Molecular Transducers of Physical Activity Consortium 4 profiled the temporal transcriptome, proteome, metabolome, lipidome, phosphoproteome, acetylproteome, ubiquitylproteome, epigenome and immunome in whole blood, plasma and 18 solid tissues in male and female Rattus norvegicus over eight weeks of endurance exercise training. The resulting data compendium encompasses 9,466 assays across 19 tissues, 25 molecular platforms and 4 training time points. Thousands of shared and tissue-specific molecular alterations were identified, with sex differences found in multiple tissues. Temporal multi-omic and multi-tissue analyses revealed expansive biological insights into the adaptive responses to endurance training, including widespread regulation of immune, metabolic, stress response and mitochondrial pathways. Many changes were relevant to human health, including non-alcoholic fatty liver disease, inflammatory bowel disease, cardiovascular health and tissue injury and recovery. The data and analyses presented in this study will serve as valuable resources for understanding and exploring the multi-tissue molecular effects of endurance training and are provided in a public repository (https://motrpac-data.org/). Temporal multi-omic analysis of tissues from rats undergoing up to eight weeks of endurance exercise training reveals widespread shared, tissue-specific and sex-specific changes, including immune, metabolic, stress response and mitochondrial pathways.

引用

页码：174 / 183

页数：35

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