Oxidative stress in breast cancer

被引：0
作者：
Faruk Tas
Hasan Hansel
Ahmet Belce
Sennur Ilvan
Andac Argon
Hakan Camlica
Erkan Topuz
机构：
[1] Istanbul University,Institute of Oncology
[2] Istanbul University,Department of Surgery Cerrahpasa Medical Faculty
[3] Istanbul University,Department of Biochemistry, Cerrahpasa Medical Faculty
[4] Istanbul University,Department of Pathology, Cerrahpasa Medical Faculty
[5] Sisli Etfal Hospital,Department of Oncology
[6] Istanbul Universitesi,Onkoloji Enstitusu, Capa
来源：
Medical Oncology | 2005年 / 22卷
关键词：
Breast cancer; catalase; GPx; MDA; oxidative stress; SOD;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The present study was undertaken to evaluate the place of oxidative stress on breast cancer. Lipid peroxidation as evidenced by malondialdehyde (MDA) and the status of the antioxidants superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were estimated in tissues of 10 fibroadenoma and 40 breast cancer patients. Lipid peroxidation in breast cancer tissues was enhanced compared to nonmalignant tissues (p<0.001). Similarly, antioxidants SOD (p<0.001) and GPx (p=0.007) in tumor tissues significantly were increased. On the contrary, CAT activity was found significantly decreased (p<0.001). We found that oxidant/antioxidant status was independent from any prognostic factors concerning breast cancer. The results of our study have shown higher oxygen-free-radical production and decreased CAT activity support the oxidative stress hypothesis in breast carcinogenesis.
引用
收藏
页码：11 / 15
页数：4
相关论文
共 51 条
  • [1] Hristozov D(2001)Evaluation of oxidative stress in patients with cancer Arch Physiol Biochem 109 331-336
  • [2] Gadjeva V(1999)Free radicals, oxidative stress and DNA metabolism in human cancer Cancer Invest 17 376-377
  • [3] Vlaykova T(2002)Tissue lipid peroxidation and antioxidant status in patients with adenocarcinoma of the breast Clin Chim Acta 325 165-170
  • [4] Dimitrov G(2002)Antioxidant profile in the circulation of patients with fibroadenoma and adenocarcinoma of the breast Clin Biochem 35 275-279
  • [5] Gonzalez RA(2000)Lipid peroxidation, free radical production and antioxidant status in breast cancer Breast Cancer Res Treat 59 163-170
  • [6] Kumaraguruparan R(1994)Antioxidant enzyme activities and oxidative stress in human breast cancer J Cancer Res Clin Oncol 120 374-377
  • [7] Subapriya R(2000)Coenzyme Q10 concentrations and antioxidant status in tissues of breast cancer patients Clin Biochem 33 279-284
  • [8] Viswanathan P(2002)The organochlorine pesticide residues and antioxidant enzyme activities in human breast tumors: is there any association? Breast Cancer Res Treat 72 173-182
  • [9] Nagini S(1994)Effect of tamoxifen on lipid peroxide and antioxidative system in postmenopausl women with breast cancer Cancer 74 78-82
  • [10] Kumaraguruparan R(1988)The critical relationship between free radicals and degrees of ischemia: evidence for tissue intolerance of marginal perfusion Plastic Reconstruct Surg 81 233-240
123456