LSD1 inhibition attenuates androgen receptor V7 splice variant activation in castration resistant prostate cancer models

被引:0
作者
Sergio Regufe da Mota
Sarah Bailey
Rosemary A. Strivens
Annette L. Hayden
Leon R. Douglas
Patrick J. Duriez
M. Teresa Borrello
Hanae Benelkebir
A. Ganesan
Graham Packham
Simon J. Crabb
机构
[1] University of Southampton,Cancer Sciences Unit and Cancer Research UK Centre
[2] Southampton General Hospital,Protein Core Facility, Cancer Research UK and Experimental Cancer Medicine Centres
[3] University of Southampton,School of Pharmacy
[4] Southampton General Hospital,undefined
[5] University of East Anglia,undefined
来源
Cancer Cell International | / 18卷
关键词
Androgen receptor; LSD1; Prostate cancer; Castration resistance; Enzalutamide; AR-V7 splice variant;
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[1]  
Niraula S(2011)Broadening horizons in medical management of prostate cancer Acta Oncol 50 141-147
[2]  
Tannock IF(2014)Enzalutamide in metastatic prostate cancer before chemotherapy N Engl J Med 371 424-433
[3]  
Beer TM(2011)Abiraterone and increased survival in metastatic prostate cancer N Engl J Med 364 1995-2005
[4]  
Armstrong AJ(2013)Abiraterone in metastatic prostate cancer without previous chemotherapy N Engl J Med 368 138-148
[5]  
Rathkopf DE(2012)Increased survival with enzalutamide in prostate cancer after chemotherapy N Engl J Med 367 1187-1197
[6]  
Loriot Y(2007)Androgen signaling and its interactions with other signaling pathways in prostate cancer BioEssays 29 1227-1238
[7]  
Sternberg CN(2014)AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer N Engl J Med 371 1028-1038
[8]  
Higano CS(2017)Clinical significance of androgen receptor splice variant-7 mRNA detection in circulating tumor cells of men with metastatic castration-resistant prostate cancer treated with first- and second-line abiraterone and enzalutamide J Clin Oncol 35 2149-2156
[9]  
Iversen P(2011)New strategies in metastatic prostate cancer: targeting the androgen receptor signaling pathway Clin Cancer Res 17 1649-1657
[10]  
Bhattacharya S(2014)Emerging mechanisms of enzalutamide resistance in prostate cancer Nat Rev Urol 11 712-716