The regulation of immune tolerance by FOXP3

被引：0
|
作者：
Ling Lu
Joseph Barbi
Fan Pan
机构：
[1] Liver Transplantation Center,Department of Immunology
[2] First Affiliated Hospital,Department of Oncology, Immunology and Hematopoiesis Division
[3] Nanjing Medical University,undefined
[4] Roswell Park Cancer Institute,undefined
[5] Sidney Kimmel Comprehensive Cancer Center,undefined
[6] Johns Hopkins University School of Medicine,undefined
来源：
Nature Reviews Immunology | 2017年 / 17卷
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学科分类号：
摘要：
Forkhead box protein P3 (FOXP3) is a crucial regulator of regulatory T (Treg) cell gene expression that is responsible for much of the suppressive potential displayed by these cells.The regulation of FOXP3 expression in Treg cells occurs through the concerted action of transcription factors and extensive epigenetic control mechanisms; furthermore, post-translational modifications are also capable of modulating FOXP3 function.These several layers of FOXP3 control are responsive to positive and negative regulation by factors in the tissue environment, including cytokines, inflammatory mediators and metabolic factors.Modulating FOXP3 expression and Treg cell function by targeting newly discovered regulatory nodes may lead to the development of new immunotherapies for cancer and autoimmune diseases.
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页码：703 / 717
页数：14
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