Genome scan for adiposity in Dutch dyslipidemic families reveals novel quantitative trait loci for leptin, body mass index and soluble tumor necrosis factor receptor superfamily 1A

被引：0
作者：
CJH van der Kallen
RM Cantor
MMJ van Greevenbroek
JMW Geurts
FG Bouwman
BE Aouizerat
H Allayee
WA Buurman
AJ Lusis
JI Rotter
TWA de Bruin
机构：
[1] Laboratory of Molecular Metabolism and Endocrinology,Department of Medicine
[2] Academic Hospital Maastricht and Cardiovascular Research Institute Maastricht,Departments of Pediatrics and Human Genetics
[3] University of Maastricht,Department of Microbiology and Molecular Genetics, Department of Medicine, and Molecular Biology Institute
[4] UCLA School of Medicine,Department of Surgery
[5] University of California,Division of Medical Genetics, Departments of Medicine and Pediatrics
[6] University of Maastricht,undefined
[7] Steven Spielberg Pediatric Research Center,undefined
[8] Cedars-Sinai Research Institute,undefined
来源：
International Journal of Obesity | 2000年 / 24卷
关键词：
obesity; leptin; TNF-α; FCH; genetic linkage analyses;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
OBJECTIVE: To search for novel genes contributing to adiposity in familial combined hyperlipidemia (FCH), a disorder characterized by abdominal obesity, hyperlipidemia and insulin resistance, using a 10 cM genome-wide scan.
引用
收藏
页码：1381 / 1391
页数：10
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共 394 条
  • [61] Bogardus C(1998)Tumor necrosis factor (TNF)-alpha induces leptin production through the p55 TNF receptor Diabetes 47 691-695
  • [62] Ravussin E(1992)The human obesity gene map: the 1997 update Biochem Biophys Res Commun 186 237-243
  • [63] Lapsys NM(undefined)Polymorphism of the beta 3-adrenergic receptor gene in morbid obesity undefined undefined undefined-undefined
  • [64] Furler SM(undefined)Beta 3-adrenergic-receptor polymorphism: a genetic marker for visceral fat obesity and the insulin resistance syndrome undefined undefined undefined-undefined
  • [65] Moore KR(undefined)Tumor necrosis factor-alpha contributes to obesity-related hyperleptinemia by regulating leptin release from adipocytes undefined undefined undefined-undefined
  • [66] Nguyen TV(undefined)BRL 49653 blocks the lipolytic actions of tumor necrosis factor-alpha: a potential new insulin-sensitizing mechanism for thiazolidinediones undefined undefined undefined-undefined
  • [67] Herzog H(undefined)Cytokines stimulate lipolysis and decrease lipoprotein lipase activity in cultured fat cells by a prostaglandin independent mechanism undefined undefined undefined-undefined
  • [68] Howard G(undefined)undefined undefined undefined undefined-undefined
  • [69] Samaras K(undefined)undefined undefined undefined undefined-undefined
  • [70] Carey DG(undefined)undefined undefined undefined undefined-undefined
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