Genome scan for adiposity in Dutch dyslipidemic families reveals novel quantitative trait loci for leptin, body mass index and soluble tumor necrosis factor receptor superfamily 1A

被引：0
作者：
CJH van der Kallen
RM Cantor
MMJ van Greevenbroek
JMW Geurts
FG Bouwman
BE Aouizerat
H Allayee
WA Buurman
AJ Lusis
JI Rotter
TWA de Bruin
机构：
[1] Laboratory of Molecular Metabolism and Endocrinology,Department of Medicine
[2] Academic Hospital Maastricht and Cardiovascular Research Institute Maastricht,Departments of Pediatrics and Human Genetics
[3] University of Maastricht,Department of Microbiology and Molecular Genetics, Department of Medicine, and Molecular Biology Institute
[4] UCLA School of Medicine,Department of Surgery
[5] University of California,Division of Medical Genetics, Departments of Medicine and Pediatrics
[6] University of Maastricht,undefined
[7] Steven Spielberg Pediatric Research Center,undefined
[8] Cedars-Sinai Research Institute,undefined
来源：
International Journal of Obesity | 2000年 / 24卷
关键词：
obesity; leptin; TNF-α; FCH; genetic linkage analyses;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
OBJECTIVE: To search for novel genes contributing to adiposity in familial combined hyperlipidemia (FCH), a disorder characterized by abdominal obesity, hyperlipidemia and insulin resistance, using a 10 cM genome-wide scan.
引用
收藏
页码：1381 / 1391
页数：10
相关论文
共 394 条
  • [1] Barrett-Connor EL(1985)Obesity, atherosclerosis, and coronary artery disease Ann Intern Med 103 1010-1019
  • [2] Bouchard C(1988)Heredity and body fat Annu Rev Nutr 8 259-277
  • [3] Perusse L(1993)Genetic models of human obesity-family studies Crit Rev Food Sci Nutr 33 339-343
  • [4] Burns TL(1990)The body-mass index of twins who have been reared apart New Engl J Med 322 1483-1487
  • [5] Moll PP(1993)Genetic and nongenetic determinants of regional fat distribution Endocr Rev 14 72-93
  • [6] Lauer RM(1996)Radioimmunoassay of leptin in human plasma Clin Chem 42 942-946
  • [7] Stunkard AJ(1994)Tumor necrosis factor alpha: a key component of the obesity-diabetes link Diabetes 43 1271-1278
  • [8] Harris JR(1995)Effects of the obese gene product on body weight regulation in ob/ob mice Science 269 540-543
  • [9] Pedersen NL(1993)Adipose expression of tumor necrosis factor-alpha: direct rolein obesity-linked insulin resistance Science 259 87-91
  • [10] McClearn GE(1998)Tumor necrosis factor-alpha acutely inhibits insulin signaling in human adipocytes: implication of the p80 tumor necrosis factor receptor Diabetes 47 515-522
12345678910