Lower relapse rates with good post-transplant outcome in alcoholic liver disease: Experience from a living donor liver transplant center

被引：13

作者：

Saigal S. ^{[1
]}

Choudhary N.S. ^{[1
]}

Yadav S.K. ^{[1
]}

Saraf N. ^{[1
]}

Kumar N. ^{[1
]}

Rai R. ^{[1
]}

Mehrotra S. ^{[2
]}

Rastogi V. ^{[2
]}

Rastogi A. ^{[1
]}

Goja S. ^{[1
]}

Bhangui P. ^{[1
]}

Ramachandra S.K. ^{[1
]}

Raut V. ^{[1
]}

Gautam D. ^{[3
]}

Soin A.S. ^{[1
]}

机构：

[1] Medanta Institute of Liver Transplantation and Regenerative Medicine, Gurgaon, Delhi (NCR)

[2] Department of Mental Health and Quality of Life, Medanta - The Medicity, Gurgaon, Delhi (NCR)

[3] Department of Histopathology, Medanta - The Medicity, Gurgaon, Delhi (NCR)

来源：

Indian Journal of Gastroenterology | 2016年 / 35卷 / 2期

关键词：

Alcoholic liver disease; Liver transplant; Living donor liver transplantation;

D O I：

10.1007/s12664-016-0646-z

中图分类号：

学科分类号：

摘要：

Introduction: Post-transplant relapse is a major factor influencing the long-term outcome in alcoholic liver disease (ALD) patients. Aims: The aim of this study was to evaluate the relapse rates following living donor liver transplantation (LDLT) in patients with ALD in the Indian context with strong family support. Methods: Of 458 patients who underwent LDLT for ALD, 408 were included in the study. Post-transplant relapse was determined by information provided by the patient and/or family by means of outpatient and e-mail questionnaire, supported by clinical/biochemical parameters/liver histopathology. Results: All except one were males, with a mean age of 46.9 ± 8.5 years. The overall rate of relapse was 9.5 % at 34.7 months (interquartile range (IQR) 15–57.6), lower than that reported in the literature from the West. The relapse rate was higher in patients with a shorter duration of pre-transplant abstinence (17.4 % and 15.4 % for recipients with pre-transplant abstinence of <3 and <6 months, respectively, p < 0.05). The overall survival was 88.5 % at 3 years. Of 39 patients with relapse, 16 (41 %) were occasional drinkers, 14 (35.8 %) were moderate drinkers, and 9 (23 %) were heavy drinkers. All the heavy drinkers presented with features of graft dysfunction. Conclusions: Good results can be obtained following LDLT for ALD, with significantly lower relapse rates in our setup as compared to the West. © 2016, Indian Society of Gastroenterology.

引用

页码：123 / 128

页数：5

共 33 条

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