Patient-derived xenografts undergo mouse-specific tumor evolution

被引：0
作者：
Uri Ben-David
Gavin Ha
Yuen-Yi Tseng
Noah F Greenwald
Coyin Oh
Juliann Shih
James M McFarland
Bang Wong
Jesse S Boehm
Rameen Beroukhim
Todd R Golub
机构：
[1] Cancer Program,Department of Medical Oncology
[2] Broad Institute of Harvard and MIT,Department of Cancer Biology
[3] Dana-Farber Cancer Institute,Department of Neurosurgery
[4] Dana-Farber Cancer Institute,Department of Medicine
[5] Brigham and Women's Hospital,Department of Medicine
[6] Harvard Medical School,Department of Pediatric Oncology
[7] Brigham and Women's Hospital,Department of Pediatrics
[8] Dana-Farber Cancer Institute,undefined
[9] Harvard Medical School,undefined
[10] Howard Hughes Medical Institute,undefined
来源：
Nature Genetics | 2017年 / 49卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
This large-scale analysis of copy number alterations (CNAs) in patient-derived xenografts (PDXs) across 24 cancer types shows that new CNAs accumulate quickly and that the specific CNAs acquired during passaging differ from those acquired during tumor evolution in patients, suggesting that PDX tumors are under distinct selection pressures from tumors in human hosts.
引用
收藏
页码：1567 / 1575
页数：8
相关论文
共 50 条
  • [11] Maintaining Tumor Heterogeneity in Patient-Derived Tumor Xenografts
    Cassidy, John W.
    Caldas, Carlos
    Bruna, Alejandra
    CANCER RESEARCH, 2015, 75 (15) : 2963 - 2968
  • [12] Patient-Derived Tumor Xenografts Why Now?
    Liu, Edison T.
    Bult, Carol J.
    Shultz, Leonard D.
    JAMA ONCOLOGY, 2016, 2 (05) : 567 - 568
  • [13] Patient Characteristics Associated with Growth of Patient-Derived Tumor Implants in Mice (Patient-Derived Xenografts)
    Guerrero, Tatiana Hernandez
    Banos, Natalia
    Nevado, Laura del Puerto
    Mahillo-Fernandez, Ignacio
    De-Speville, Bernard Doger
    Calvo, Emiliano
    Wick, Michael
    Garcia-Foncillas, Jesus
    Moreno, Victor
    CANCERS, 2023, 15 (22)
  • [14] CHARACTERIZATION OF PATIENT-DERIVED TUMOR SPHERES AND XENOGRAFTS FOR GLIOBLASTOMA
    Kijima, Noriyuki
    Kanematsu, Daisuke
    Shofuda, Tomoko
    Yoshioka, Ema
    Handa, Yukako
    Moriuchi, Shusuke
    Nonaka, Masahiro
    Okita, Yoshiko
    Tsuyuguchi, Naohiro
    Fukai, Junya
    Higuchi, Yuichiro
    Suemizu, Hiroshi
    Kanemura, Yonehiro
    NEURO-ONCOLOGY, 2017, 19 : 258 - 258
  • [15] The future of patient-derived tumor xenografts in cancer treatment
    Sia, Daniela
    Moeini, Agrin
    Labgaa, Ismail
    Villanueva, Augusto
    PHARMACOGENOMICS, 2015, 16 (14) : 1671 - 1683
  • [16] Patient-derived murine xenografts
    Annette Fenner
    Nature Reviews Urology, 2015, 12 (10) : 536 - 536
  • [17] MET activation and Cetuximab resistance in patient-derived tumor xenografts
    Krumbach, Rebekka
    Schuler, Julia
    Hofmann, Michael
    Fiebig, Heinz-Herbert
    Beckers, Thomas
    MOLECULAR CANCER THERAPEUTICS, 2009, 8 (12)
  • [18] Assessment of Hypoxia in the Stroma of Patient-Derived Pancreatic Tumor Xenografts
    Lohse, Ines
    Lourenco, Corey
    Ibrahimov, Emin
    Pintilie, Melania
    Tsao, Ming-Sound
    Hedley, David W.
    CANCERS, 2014, 6 (01): : 459 - 471
  • [19] Opportunities and challenges of patient-derived models in cancer research: patient-derived xenografts, patient-derived organoid and patient-derived cells
    Hou, Xiaoying
    Du, Cong
    Lu, Ligong
    Yuan, Shengtao
    Zhan, Meixiao
    You, Pengtao
    Du, Hongzhi
    WORLD JOURNAL OF SURGICAL ONCOLOGY, 2022, 20 (01)
  • [20] Opportunities and challenges of patient-derived models in cancer research: patient-derived xenografts, patient-derived organoid and patient-derived cells
    Xiaoying Hou
    Cong Du
    Ligong Lu
    Shengtao Yuan
    Meixiao Zhan
    Pengtao You
    Hongzhi Du
    World Journal of Surgical Oncology, 20
12345