Patient-derived xenografts undergo mouse-specific tumor evolution

被引：0
|
作者：
Uri Ben-David
Gavin Ha
Yuen-Yi Tseng
Noah F Greenwald
Coyin Oh
Juliann Shih
James M McFarland
Bang Wong
Jesse S Boehm
Rameen Beroukhim
Todd R Golub
机构：
[1] Cancer Program,Department of Medical Oncology
[2] Broad Institute of Harvard and MIT,Department of Cancer Biology
[3] Dana-Farber Cancer Institute,Department of Neurosurgery
[4] Dana-Farber Cancer Institute,Department of Medicine
[5] Brigham and Women's Hospital,Department of Medicine
[6] Harvard Medical School,Department of Pediatric Oncology
[7] Brigham and Women's Hospital,Department of Pediatrics
[8] Dana-Farber Cancer Institute,undefined
[9] Harvard Medical School,undefined
[10] Howard Hughes Medical Institute,undefined
来源：
Nature Genetics | 2017年 / 49卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
This large-scale analysis of copy number alterations (CNAs) in patient-derived xenografts (PDXs) across 24 cancer types shows that new CNAs accumulate quickly and that the specific CNAs acquired during passaging differ from those acquired during tumor evolution in patients, suggesting that PDX tumors are under distinct selection pressures from tumors in human hosts.
引用
收藏
页码：1567 / 1575
页数：8
相关论文
共 50 条
  • [1] Patient-Derived Xenografts Undergo Mouse-Specific Tumor Evolution
    Muller, Elmi
    Adigbli, George
    Issa, Fadi
    TRANSPLANTATION, 2018, 102 (02) : 179 - 182
  • [2] Patient-derived xenografts undergo mouse-specific tumor evolution
    Ben-David, Uri
    Ha, Gavin
    Tseng, Yuen-Yi
    Greenwald, Noah F.
    Oh, Coyin
    Shih, Juliann
    McFarland, James M.
    Wong, Bang
    Boehm, Jesse S.
    Beroukhim, Rameen
    Golub, Todd R.
    CANCER RESEARCH, 2018, 78 (13)
  • [3] Patient-derived xenografts undergo mouse-specific tumor evolution
    Ben-David, Uri
    Ha, Gavin
    Tseng, Yuen-Yi
    Greenwald, Noah F.
    Oh, Coyin
    Shih, Juliann
    McFarland, James M.
    Wong, Bang
    Boehm, Jesse S.
    Beroukhim, Rameen
    Golub, Todd R.
    NATURE GENETICS, 2017, 49 (11) : 1567 - +
  • [4] Absence of mouse-specific tumor evolution in patient-derived cancer xenografts
    Giordano, Jessica
    Woo, Xing Yi
    Srivastava, Anuj
    Zhao, Zi-Ming
    Lloyd, Michael W.
    de Bruijn, Roebi
    Suh, Yun-Suhk
    Galimi, Francesco
    Bertotti, Andrea
    Lafferty, Adam
    O'Farrell, Alice C.
    Modave, Elodie
    Lambrechts, Diether
    ter Brugge, Petra
    Serra, Violeta
    Marangoni, Elisabetta
    El Botty, Rania
    Kim, Jong-Il
    Yang, Han-Kwang
    Lee, Charles
    Dean, Dennis A.
    Davis-Dusenbery, Brandi
    Evrard, Yvonne A.
    Doroshow, James H.
    Welm, Alana L.
    Welm, Bryan E.
    Lewis, Michael T.
    Fang, Bingliang
    Roth, Jack
    Meric-Bernstam, Funda
    Herlyn, Meenhard
    Davies, Michael
    Ding, Li
    Li, Shunqiang
    Govindan, Ramaswamy
    Moscow, Jeffrey A.
    Bult, Carol J.
    Isella, Claudio
    Trusolino, Livio
    Byrne, Annette T.
    Jonkers, Jos
    Chuang, Jeffrey H.
    Medico, Enzo
    CANCER RESEARCH, 2020, 80 (16)
  • [5] Patient Derived Xenografts Highlight Mouse-Specific Tumor Evolution Patterns and Genomic Diversity of Multiple Myeloma
    Becker, Nathan
    Liu, Enze
    Sudha, Parvathi
    Mikulasova, Aneta
    Johnson, Travis S.
    Suvannasankha, Attaya
    Abu Zaid, Mohammad Issam
    Abonour, Rafat
    Walker, Brian A.
    BLOOD, 2022, 140 : 9970 - 9971
  • [6] Patient-Derived Tumor Xenografts: Transforming Clinical Samples into Mouse Models
    Siolas, Despina
    Hannon, Gregory J.
    CANCER RESEARCH, 2013, 73 (17) : 5315 - 5319
  • [7] Detection of mouse viruses in patient-derived xenografts
    Alexandra Le Bras
    Lab Animal, 2021, 50 : 119 - 119
  • [8] Detection of mouse viruses in patient-derived xenografts
    Le Bras, Alexandrai
    LAB ANIMAL, 2021, 50 (05) : 119 - 119
  • [9] Patient-derived tumor immune microenvironments in patient-derived xenografts of lung cancer
    Pu, Xingxiang
    Zhang, Ran
    Wang, Li
    Chen, Yungchang
    Xu, Yi
    Pataer, Apar
    Meraz, Ismail M.
    Zhang, Xiaoshan
    Wu, Shuhong
    Wu, Lin
    Su, Dan
    Mao, Weimin
    Heymach, John V.
    Roth, Jack A.
    Swisher, Stephen G.
    Fang, Bingliang
    JOURNAL OF TRANSLATIONAL MEDICINE, 2018, 16
  • [10] Patient-derived tumor immune microenvironments in patient-derived xenografts of lung cancer
    Xingxiang Pu
    Ran Zhang
    Li Wang
    Yungchang Chen
    Yi Xu
    Apar Pataer
    Ismail M. Meraz
    Xiaoshan Zhang
    Shuhong Wu
    Lin Wu
    Dan Su
    Weimin Mao
    John V. Heymach
    Jack A. Roth
    Stephen G. Swisher
    Bingliang Fang
    Journal of Translational Medicine, 16
12345