Distribution of trace elements in normal and tumor-bearing mice using the multitracer technique

被引：0
作者：
X. Wang
J. Tian
X. M. Yin
X. Zhang
Zh. Qin
Z. W. Li
Q. Z. Wang
Sh. B. Li
机构：
[1] Chinese Academy of Sciences,State Key Laboratory for Oxo
[2] Chinese Academy of Sciences,synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics
[3] Chinese Academy of Sciences,Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics
[4] Lanzhou University,Institute of Modern Physics
来源：
Biological Trace Element Research | 2001年 / 81卷
关键词：
Multitracer technique; distribution; biotrace element; tumor mice;
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中图分类号：
学科分类号：
摘要：
A multitracer solution obtained from the nuclear reaction of selenium with 25-MeV/nucleon 40Ar ions was orally administered to normal and tumor-bearing Balb/c male mice. After 96 h, the mice were sacrificed and the elemental distribution was determined in various tissues, organs, and blood. The uptake of Na, Rb, Ga, Sc, V, Cr, Mn, Co, Fe, Zn, Y, Zr, Tc, Ru, Ag, and In in normal and, except for zinc, in tumor-bearing mice was simultaneously detected. Most elements were distributed in about the same manner in the skin and liver of animals in both groups. The distribution of Rb, Ga, V, Cr, Tc, and In showed little or no significant differences between the two study groups. The distribution of Na, Mn, Fe, Ag, Sc, and Co showed significant differences between normal and tumor-bearing mice. In the blood, spleen, and kidney of the normal mice, there was good absorption of Na, Mn, Fe, Ag, Co, and Zn. In the heart, these elements were well absorbed, except for Na and Mn.
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页码：177 / 183
页数：6
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