Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis

被引：0
作者：
Sara Lovisa
Valerie S LeBleu
Björn Tampe
Hikaru Sugimoto
Komal Vadnagara
Julienne L Carstens
Chia-Chin Wu
Yohannes Hagos
Birgitta C Burckhardt
Tsvetelina Pentcheva-Hoang
Hersharan Nischal
James P Allison
Michael Zeisberg
Raghu Kalluri
机构：
[1] Metastasis Research Center,Department of Cancer Biology
[2] University of Texas M.D. Anderson Cancer Center,Department of Nephrology and Rheumatology
[3] Göttingen University Medical Center,Department of Genomic Medicine
[4] Georg August University,Department of Immunology
[5] University of Texas M.D. Anderson Cancer Center,undefined
[6] Institute of Systemic Physiology and Pathophysiology,undefined
[7] Göttingen University Medical Center,undefined
[8] Georg August University,undefined
[9] University of Texas M.D. Anderson Cancer Center,undefined
来源：
Nature Medicine | 2015年 / 21卷
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学科分类号：
摘要：
During renal fibrosis epithelial cells undergo a partial epithelial-to-mesenchymal transition that can be targeted to reverse established disease.
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页码：998 / 1009
页数：11
相关论文
共 73 条
[1]  
Zeisberg M(2013)Cellular mechanisms of tissue fibrosis. 1. Common and organ-specific mechanisms associated with tissue fibrosis Am. J. Physiol. Cell Physiol. 304 C216-C225
[2]  
Kalluri R(2013)Lifetime incidence of CKD stages 3–5 in the United States Am. J. Kidney Dis. 62 245-252
[3]  
Grams ME(2012)Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis Nat. Med. 18 396-404
[4]  
Sugimoto H(2013)Origin and function of myofibroblasts in kidney fibrosis Nat. Med. 19 1047-1053
[5]  
LeBleu VS(2010)Methylation determines fibroblast activation and fibrogenesis in the kidney Nat. Med. 16 544-550
[6]  
Bechtel W(2002)Evidence that fibroblasts derive from epithelium during tissue fibrosis J Clin. Invest. 110 341-350
[7]  
Iwano M(2008)Fibroblasts emerge via epithelial-mesenchymal transition in chronic kidney fibrosis Front. Biosci. 13 6991-6998
[8]  
Zeisberg M(2008)Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition J. Am. Soc. Nephrol. 19 2282-2287
[9]  
Kalluri R(2014)Molecular mechanisms of epithelial-mesenchymal transition Nat. Rev. Mol. Cell Biol. 15 178-196
[10]  
Zeisberg EM(2012)New insights into the regulation of epithelial-mesenchymal transition and tissue fibrosis Int. Rev. Cell Mol. Biol. 294 171-221
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