Stereoselective interaction between the CYP2C8 inhibitor gemfibrozil and racemic ibuprofen

[1] Adams SS(1976)Pharmacological differences between the optical isomers of ibuprofen: evidence for metabolic inversion of the (−)-isomer J Pharm Pharmacol 28 256-257

[2] Bresloff P(1992)Enantioselective pharmacodynamics and pharmacokinetics of chiral non-steroidal anti-inflammatory drugs Eur J Clin Pharmacol 42 237-256

[3] Mason CG(1985)Stereoselective disposition of ibuprofen enantiomers in man Br J Clin Pharmacol 19 669-674

[4] Evans AM(1997)Regioselective and stereoselective metabolism of ibuprofen by human cytochrome P450 2C Biochem Pharmacol 54 33-41

[5] Lee EJ(2002)Enantiospecific effects of cytochrome P450 2C9 amino acid variants on ibuprofen pharmacokinetics and on the inhibition of cyclooxygenases 1 and 2 Clin Pharmacol Ther 72 62-75

[6] Williams K(2005)The effect of the cytochrome P450 CYP2C8 polymorphism on the disposition of (R)-ibuprofen enantiomer in healthy subjects Br J Clin Pharmacol 59 62-69

[7] Day R(2004)Interindividual variability in ibuprofen pharmacokinetics is related to interaction of cytochrome P450 2C8 and 2C9 amino acid polymorphisms Clin Pharmacol Ther 76 119-127

[8] Graham G(2002)Gemfibrozil inhibits CYP2C8-mediated cerivastatin metabolism in human liver microsomes Drug Metab Dispos 30 1352-1356

[9] Champion D(2002)Gemfibrozil greatly increases plasma concentrations of cerivastatin Clin Pharmacol Ther 72 685-691

[10] Hamman MA(2003)Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics and pharmacodynamics of repaglinide: potentially hazardous interaction between gemfibrozil and repaglinide Diabetologia 46 347-351

[1] Adams SS(1976)Pharmacological differences between the optical isomers of ibuprofen: evidence for metabolic inversion of the (−)-isomer J Pharm Pharmacol 28 256-257

[2] Bresloff P(1992)Enantioselective pharmacodynamics and pharmacokinetics of chiral non-steroidal anti-inflammatory drugs Eur J Clin Pharmacol 42 237-256

[3] Mason CG(1985)Stereoselective disposition of ibuprofen enantiomers in man Br J Clin Pharmacol 19 669-674

[4] Evans AM(1997)Regioselective and stereoselective metabolism of ibuprofen by human cytochrome P450 2C Biochem Pharmacol 54 33-41

[5] Lee EJ(2002)Enantiospecific effects of cytochrome P450 2C9 amino acid variants on ibuprofen pharmacokinetics and on the inhibition of cyclooxygenases 1 and 2 Clin Pharmacol Ther 72 62-75

[6] Williams K(2005)The effect of the cytochrome P450 CYP2C8 polymorphism on the disposition of (R)-ibuprofen enantiomer in healthy subjects Br J Clin Pharmacol 59 62-69

[7] Day R(2004)Interindividual variability in ibuprofen pharmacokinetics is related to interaction of cytochrome P450 2C8 and 2C9 amino acid polymorphisms Clin Pharmacol Ther 76 119-127

[8] Graham G(2002)Gemfibrozil inhibits CYP2C8-mediated cerivastatin metabolism in human liver microsomes Drug Metab Dispos 30 1352-1356

[9] Champion D(2002)Gemfibrozil greatly increases plasma concentrations of cerivastatin Clin Pharmacol Ther 72 685-691

[10] Hamman MA(2003)Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics and pharmacodynamics of repaglinide: potentially hazardous interaction between gemfibrozil and repaglinide Diabetologia 46 347-351