Structure of the 30S translation initiation complex

被引:0
作者
Angelita Simonetti
Stefano Marzi
Alexander G. Myasnikov
Attilio Fabbretti
Marat Yusupov
Claudio O. Gualerzi
Bruno P. Klaholz
机构
[1] Institute of Genetics and of Molecular and Cellular Biology,Department of Structural Biology and Genomics
[2] Inserm,Department of Biology MCA
[3] U596,undefined
[4] Illkirch F-67404,undefined
[5] France ,undefined
[6] CNRS,undefined
[7] UMR7104,undefined
[8] Illkirch F-67404,undefined
[9] France ,undefined
[10] Université Louis Pasteur,undefined
[11] Architecture et Réactivité de l’ARN,undefined
[12] UPR 9002 CNRS,undefined
[13] Institute of Molecular and Cellular Biology,undefined
[14] 15 rue R. Descartes,undefined
[15] 67084 Strasbourg,undefined
[16] France ,undefined
[17] Laboratory of Genetics,undefined
[18] University of Camerino,undefined
来源
Nature | 2008年 / 455卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
Proteins known as initiation factors (IFs) help to position the 30S subunit of the ribosome correctly on the mRNA start site so that the proper reading frame is engaged. After formation of this 30S initiation complex, the 50S ribosomal subunit binds and the IFs are released. In this work, Simonetti et al. use cryo-electron microscopy to examine the position of the mRNA, initiator tRNA, IF1 and IF2 in the 30S particle. From this structure, they predict how the 50S subunit interacts with the 30S initiation complex, and how GTP bound to IF2 is positioned towards the incoming GTPase-activated centre of the 50S.
引用
收藏
页码:416 / 420
页数:4
相关论文
共 50 条
  • [41] DEMOLISHING THE 30S
    HILLIER, B
    TLS-THE TIMES LITERARY SUPPLEMENT, 1979, (4004): : 120 - 120
  • [42] 30S CERAMICS
    PINKHAM, R
    ARCHITECTURAL REVIEW, 1977, 162 (967) : 134 - 134
  • [43] PHOTOGRAPHY IN THE 30S
    LICHTENSTEIN, T
    ARTS MAGAZINE, 1984, 58 (07): : 39 - 40
  • [44] THE LESSONS OF THE 30S
    STONEMAN, WH
    INTERNATIONAL AFFAIRS, 1963, 39 (02) : 227 - 237
  • [45] VIEWPOINT + 30S
    MADGE, C
    TLS-THE TIMES LITERARY SUPPLEMENT, 1979, (4004): : 119 - 119
  • [46] 30S - NOW AND THEN
    AARON, D
    AMERICAN SCHOLAR, 1966, 35 (03) : 490 - 494
  • [47] Crowd 30s
    Piedra Cobo, Lorena Yael
    Pinto Morales, Jean Paul
    POLICIA Y SEGURIDAD PUBLICA, 2016, 6 (02): : 379 - 383
  • [48] BENN IN THE 30S
    SCHRODER, J
    DEUTSCHE VIERTELJAHRSSCHRIFT FUR LITERATURWISSENSCHAFT UND GEISTESGESCHICHTE, 1979, 53 (02): : 326 - 336
  • [49] THE 30S REVISITED
    ZABEL, B
    ARTS MAGAZINE, 1983, 58 (03): : 17 - 17
  • [50] BACK TO THE 30S
    LIPSEY, D
    NEW SOCIETY, 1980, 53 (928): : 403 - 405